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. 2021 Aug 26;26(17):5170. doi: 10.3390/molecules26175170

Table 3.

Analogues of nitroxide labeled pyrimidines.

Compounds X NR1R2 IC50 (µM)
HeLa A-549 Hep-G2 LoVo
41a NO2 graphic file with name molecules-26-05170-i002.jpg 55.56 ± 4.01 33.16 ± 3.08 28.73 ± 1.95 41.24 ± 3.52
41b NO2 graphic file with name molecules-26-05170-i003.jpg 17.49 ± 0.82 1.96 ± 0.12 56.83 ± 4.39 39.73 ± 2.95
41c NO2 graphic file with name molecules-26-05170-i004.jpg 25.33 ± 2.33 10.25 ± 1.08 13.08 ± 1.21 27.82 ± 2.47
41d NO2 graphic file with name molecules-26-05170-i005.jpg 7.36 ± 0.82 1.14 ± 0.09 7.36 ± 0.92 26.81 ± 2.54
41e NO2 graphic file with name molecules-26-05170-i006.jpg 29.13 ± 1.21 15.32 ± 1.21 37.51 ± 1.21 >100
41f NO2 graphic file with name molecules-26-05170-i007.jpg 3.79 ± 1.21 0.74 ± 0.08 6.87 ± 0.58 12.53 ± 1.02
41g NO2 graphic file with name molecules-26-05170-i008.jpg 11.95 ± 1.05 1.04 ± 0.13 26.44 ± 2.3 27.01 ± 2.57
41h F graphic file with name molecules-26-05170-i009.jpg 5.68 ± 0.62 0.88 ± 0.07 10.82 ± 0.89 11.97 ± 1.33
41i F graphic file with name molecules-26-05170-i010.jpg 11.20 ± 1.07 2.12 ± 0.18 10.80 ± 1.28 42.18 ± 3.91
41j F graphic file with name molecules-26-05170-i011.jpg 11.20 ± 1.07 2.12 ± 0.18 10.80 ± 1.28 42.18 ± 3.91
41k F graphic file with name molecules-26-05170-i012.jpg 5.23 ± 0.47 2.31 ± 0.31 11.53 ± 1.25 21.91 ± 2.03
41l F graphic file with name molecules-26-05170-i013.jpg 2.72 ± 0.25 0.89 ± 0.05 5.73 ± 0.39 11.41 ± 1.08
41m F graphic file with name molecules-26-05170-i014.jpg 14.35 ± 1.09 13.17 ± 1.13 22.61 ± 2.05 35.52 ± 2.71
41n F graphic file with name molecules-26-05170-i015.jpg 31.73 ± 2.86 12.37 ± 1.19 19.82 ± 1.56 53.62 ± 4.96
VX-680 graphic file with name molecules-26-05170-i016.jpg 46.20 ± 4.08 35.80 ± 3.33 53.30 ± 5.82 45.30 ± 4.97
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