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The mean value of EC50 (nM) of the proliferation inhibition for selected MLLr cell lines after 15-day treatment (mean value of two independent experiments run in triplicate and standard error).
| Cell Line | Dia2 | EPZ-5676 | Doubling Time |
|---|---|---|---|
| MV4-11 (AF4) | 93 ± 4 | 21 ± 1 | 12 h |
| KOPN8 (ENL) | 63 ± 2 | 86 ± 4 | 48 h |
| NOMO-1 (AF9) | 660 ± 20 | 562 ± 15 | 30 h |
| MOLM-13 (AF9) | 120 ± 10 | 92 ± 2 | 22 h |
