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Antiproliferative activity of compounds 1–5.
| Compounds | IC50 (μM) a | ||
|---|---|---|---|
| A549 | H1299 | MRC-5 | |
| 1 | 3.1 c,d | 7.3 c,d | >100 |
| 2 | 2.8 c,d | 7.3 c,d | >100 |
| 3 | 2.3 c,d | 4.0 c,d | >100 |
| 4 | 3.1 c,d | 6.8 c,d | 58.2 |
| 5 | 7.9 c,d | 8.4 c,d | 36.8 |
| DDP b | 13.3 | 24.5 | 49.0 |
a IC50 values represent the mean of independent triplicate experiments (n = 3), and the statistically significant differences were analyzed using Mann-Whitney; b DDP: Cis-platin used as a positive control; c p < 0.001 vs the DDP group; d p < 0.001 vs the MRC-5 group.
