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. 2021 Aug 25;26(17):5141. doi: 10.3390/molecules26175141

Figure 5.

Figure 5

In vivo imaging of GB cell and GSC invasion in the brain of zebrafish embryos. Embryos 72 h after the xenotransplantation of (A) U373eGFP, (B) U87DsRed and (C) NCH421k eGFPcells in the brain (visible as red and green fluorescence) without (control) or with the TRIM28 nanobody NB237. Data are shown as means ± S.D., dots on graphs (A–C) represent each embryo. GB xenograft diameter at 72 h was normalized to GB xenograft diameter at 24 h after xenotransplantation to determine the relative cell invasion. Number of embryos in control and with NB237 in the experiment with U373 n = 37–50, U87 n = 94–108, NCH421k n = 13–38. Statistical analyses were performed using GraphPad Prism software, using Mann–Whitney test, * p < 0.05, vs. control group.