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Effect of TBP mutations on activation by VP16 and AP2. (A and B) Transfections contained 1 μg of the TBP expression vectors and 100 ng of the G4-VP16 or G4-AP2 expression vector. (C) The effects of mutations in TBP on physical and functional interactions with hTAFII28 are summarized. WT, wild type. Exposed residues are underlined.
