Figure 9.

Anti-biofilm activity of iron oxide-encapsulated vesicles as a function of drug and SPION loading. (a) Tile scans of the Live (green) and dead (red) bacteria by laser scanning confocal microscopy after 24 h within the magnetic field (pointed by dash line) at different concentrations (1 × stock equals to 100 μg mL⁻¹ IOP; 50 μg mL⁻¹ methicillin). (b) Three-dimensional reconstruction of z-stacks of the biofilm. (c) The percentage of biofilm volume occupied by live and dead bacteria as a function of biofilm depth (0 μm = bottom) [111] (Reprinted with permission from [111]).