Table 2.
Summary of relevant modified residues on apoB-100 from the literature. We summarize in this table the main changes in apoB-100 notified in the literature.
| Modification | Tested Condition | Modified Residues | Reference |
|---|---|---|---|
| oxCys oxLys oxTrp oxMet |
LDL oxidized by HOCl | Cys61/185/234/451/4190/3734/3890 Lys120 Trp1114/1210/1893/3567 Met3569 |
[39] |
| oxMet4 | ApoB-100 in vitro by MPO | Met4 | [40] |
| oxTy oxPhe |
LDL in vivo | Tyr 103/413/666/2524/3490/3791/4088 Phe 3965 |
[41] |
| oxTy oxTrp |
Hydroxyl radical and peroxynitrite | Tyr 583 and Trp 2524 | [42] |
| oxTy | Hydroxyl radical and HOCl | Tyr 144, Tyr 276, Tyr 4451 and Tyr 4509 | |
| oxTy | Hydroxyl radical and peroxynitrite and HOCl | Tyr 3295 | |
| oxTyr oxTrp |
HOCl | Tyr 3139 and Trp 3153 | |
| oxTrp | Trp 4369 | ||
| oxMet oxTrp |
Patients and volunteers | Met 4/4192 Trp 1114/3536 |
[43] |
| oxMet oxTrp Cl-Tyr dioxTrp |
Patients only | Met 2499 Trp 2894/3606 Tyr 76/102/125/749 Trp 4369 |
|
| oxHis oxTrp oxLys |
Patients | H2245, H2253, H3960 W1114 Lys293 |
[44] |