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. 2021 Sep 11;217:104421. doi: 10.1016/j.chemolab.2021.104421

Table 3.

Calculated docking scores (in Kcal/mol) and binding features for the COVID-19 drug candidates against SARS-CoV-2 Spike protein S1.

Compound Code Docking score (Kcal/mol) Binding Features (Hydrogen bond)
Ceftazidime −6.36 LYS403, GLY504, TYR505
3a −5.23 ARG408
3b −5.58 ASP406, GLN409, VAL417, TYR453, GLY496
3c −5.71 LYS403, ARG408, VAL417
3d −6.07 LYS403, ARG408
3e −5.72 LYS403, ASP406, GLY496
3f −5.66 ASP406, GLY496
3g −5.78 LYS403, GLN409
3h −6.03 ARG408, THR415
3i −5.52 LYS403, THR415
4a −6.44 ARG408, THR415, GLY496
4b −7.15 LYS403, ASP406, GLN409
4c −7.22 LYS403, ARG408, GLY496