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. 2021 Sep 11;217:104421. doi: 10.1016/j.chemolab.2021.104421

Table 5.

Calculated docking scores (in Kcal/mol) and binding features for the COVID-19 drug candidates against SARS-CoV-2nsp16.

Compound Code Docking score (Kcal/mol) Binding Features (Hydrogen bond)
Sinefungin −7.35 ASN6841, ASP6897, ASP6912, CYS6913
3a −7.09 ASN6841, LEU6898, CYS6913, MET6929
3b −6.67 LYS6844, ASP6897
3c −7.16 ASP6912, ASP6897
3d −7.46 LYS6844, ASP6897
3e −7.26 ASN6841, ASP6897
3f −7.32 ASP6897, ASP6912, LYS6935
3g −7.40 ASP6897, LYS6935
3h −7.47 ASN6841, ASP6897, MET6929, TYR6930
3i −7.09 ASN6841, GLY6871, CYS6913, ASP6928,
4a −8.65 ASP6912, TYR6930, LYS6968, ASN6996
4b −8.84 ASN6841, GLY6869, ASP6897, ASN6996
4c −8.89 ASP6873, ASP6912, ASP6928