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. 2021 Sep 10;40:286. doi: 10.1186/s13046-021-02070-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — PTX distribution in SKOV3 and SKOV3/HAS3 tumors 4 h after a single PTX treatment, with or without PEGPH20 pre-treatment. Three tumours were analysed for each group. A Mass spectrometry images. One representative section of three analysed for each tumour is shown. B GLSZM features in SKOV3 and C SKOV3/HAS3 tumours. A selected panel of features (mean, CV%, LZE-Large-Zone Emphasis, HGZE-High Grey-level Zone Emphasis, IV-Intensity Variability, GLNn-normalised Grey-Level Non-uniformity and DHI-Drug Homogeneity Index) describing drug distribution and influenced by PEGPH20 pre-treatment is presented. The mean value of each feature was rescaled to the PTX mean for comparison (*p-value< 0.05). D Tumour concentrations of PTX measured by HPLC in the second half of the same tumours analysed for MSI