Fig.6.

PGM1 expression downregulation enhances orlistat-induced apoptosis under glucose deprivation. a Flow cytometry to detect the apoptosis of BGC-823 and MKN-28 cells treated with DMSO, 20 μM, 40 μM or 60 μM orlistat for 24 h under the NG condition. b Flow cytometry to detect the apoptosis of BGC-823 and MKN-28 cells with knockdown of PGM1 or NC and treated with DMSO or 60 μM orlistat for 24 h under the LG condition. Data are shown as the mean ± SD. **P < 0.01, ***P < 0.001, n.s. no significant. PGM1: Phosphoglucomutase 1; NC: negative control; DMSO: dimethyl sulphoxide; NG: normal glucose, 10 mM glucose in medium; LG: low glucose, 2.5 mM glucose in medium; SD: standard deviation