Table 3.
Epigenome-wide association study results for CpG sites that yielded significant associations after Bonferroni adjustment
| CpG | Location | Gene annotation | Coefficient (m-value) | p value (Raw) | p value (Adj) | Coefficienta (beta-value) | Brain-buccal correlation |
|---|---|---|---|---|---|---|---|
| Model 1: Physical Risk vs. Typical | |||||||
| cg25123362 | Chr10: 133793734 | BNIP3 (Body) | − 0.25 | 2.76E−11 | 1.95E−05 | − 0.05 | − 0.09 |
| Model 1: Psychological Risk vs. Typical | |||||||
| cg08930413 | Chr7: 151548036 | PRKAG2 (Body) | − 0.28 | 2.11E−08 | 1.49E−02 | − 0.04 | 0.22 |
| Model 2: Cumulative Prenatal Risk | |||||||
| cg16999677 | Chr5: 843982 | ZDHHC11 (Body) | − 2.05 | 6.85E−08 | 4.84E−02 | − 0.05 | 0.61** |
| cg05324191 | Chr1: 116994757 | LOC101929023 (Body) | 1.03 | 1.30E−09 | 9.18E−04 | 0.02 | − 0.33 |
| cg01533736 | Chr20: 22542854 | LINC00261 (Body) | − 1.18 | 1.17E−09 | 8.25E−04 | − 0.03 | 0.40 |
| cg00569188 | Chr21: 41122530 | IGSF5 (Body) | − 1.28 | 4.61E−08 | 3.26E−02 | − 0.03 | − 0.17 |
| cg09979763 | Chr1: 245499904 | KIF26B (Body) | − 2.02 | 4.23E−08 | 2.99E−02 | − 0.03 | − 0.07 |
| cg11420269 | Chr16: 70516713 | COG4 (Body; ExonBnd) | − 1.46 | 2.07E−08 | 1.46E−02 | − 0.03 | 0.02 |
| cg27514986 | Chr15: 39486981 | C15orf54+ | 2.78 | 9.74E−09 | 6.88E−03 | 0.05 | 0.19 |
| cg05636131 | Chr7: 148844053 | ZNF398 (5’ UTR; TSS1500) | − 1.09 | 6.93E−08 | 4.90E−02 | − 0.02 | 0.42‡ |
| cg11531492 | Chr3: 125673505 | ROPN1B+ | − 2.63 | 6.56E−08 | 4.63E−02 | − 0.05 | − 0.08 |
| cg26760502 | Chr14: 105493800 | CDCA4+ | − 0.88 | 4.89E−08 | 3.45E−02 | − 0.01 | − 0.09 |
| cg19573457 | Chr22: 25893657 | CRYBB2P1+ | − 1.68 | 2.17E−08 | 1.53E−02 | − 0.04 | 0.44* |
| cg01284858 | Chr10: 123902371 | TACC2 (5’UTR; Body) | 3.61 | 6.20E−09 | 4.38E−03 | 0.06 | − 0.32 |
| cg12155575 | Chr3: 186965150 | MASP1 (Body) | − 1.16 | 8.97E−09 | 6.33E−03 | − 0.03 | 0.08 |
| cg11221492 | Chr14: 36790270 | MBIP (TSS1500) | − 0.90 | 3.92E−08 | 2.77E−02 | − 0.01 | 0.54* |
| cg22102865 | Chr7: 148844067 | ZNF398 (TSS1500; 5’ UTR) | − 1.24 | 1.37E−08 | 9.64E−03 | − 0.02 | 0.46* |
aNote that the coefficient for cumulative risk models represents the expected increase in % DNAm associated with a 10% increase in risk. ‡p < .10, *p < .05, **p < .01, + indicates closest gene. Adjusted p-value is Bonferroni corrected