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. 2021 Sep 7;15:3773–3781. doi: 10.2147/DDDT.S322393

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© 2021 Hu et al.

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The pore-forming process of two β-PFTs. The water-soluble monomers S subunits (HlgA and HlgC) and one F subunit (HlgB) of γ-hemolysin target the receptors C5aR and C5L2 on the cell membrane. These proteins form beta-barrel pores that span the phospholipid bilayer. LukAB are pre-assembled into heterodimers in solution. Four LukAB heterodimers form an octamer on the cell membrane through direct interact with the receptor CD11b. The potential therapeutic targets are highlight by pentagram.