Table 1.
Characteristics of patients with inv(16)
| Variable | Total |
|---|---|
| n | 264 |
| Age (median [range]) | 49 [5-78] |
| Sex, n (%) | |
| Female | 129 (48.9) |
| Male | 117 (44.3) |
| Missing | 18 (6.8) |
| WBC at Diagnosis (109/L) (median [range]) | 21.30 [1-373] |
| Missing n (%) | 5 (1.9) |
| AML type, n (%) | |
| Primary | 219 (83.0) |
| Secondary | 32 (12.1) |
| Missing | 13 (4.9) |
| Chromosome 4 abnormalities, n (%) | |
| No | 243 (92.0) |
| Yes | 5 (1.9) |
| Missing | 16 (6.1) |
| Chromosome 5 or 7 abnormalities, n (%) | |
| No | 233 (88.3) |
| Yes | 15 (5.7) |
| Missing | 16 (6.1) |
| +8, n (%) | |
| No | 212 (80.3) |
| Yes | 36 (13.6) |
| Missing | 16 (6.1) |
| Chromosome 9 abnormalities, n (%) | |
| No | 243 (92.0) |
| Yes | 5 (1.9) |
| Missing | 16 (6.1) |
| + 22, n (%) | |
| No | 208 (78.8) |
| Yes | 40 (15.2) |
| Missing | 16 (6.1) |
| −X ,n (%) | |
| No | 245 (92.8) |
| Yes | 3 (1.1) |
| Missing | 16 (6.1) |
| −Y,n (%) | |
| No | 239 (90.5) |
| Yes | 9 (3.4) |
| Missing | 16 (6.1) |
| Number of Chromosomes, n (%) | |
| <46 | 6 (2.3) |
| =46 | 180 (68.2) |
| >46 | 62 (23.5) |
| Missing | 16 (61) |
| KIT D816V mutation, n (%) | |
| Negative | 135 (51.1) |
| Positive | 29 (11.0) |
| Missing | 100 (37.9) |
| AlloHCT, n (%) | 92 (34.8) |
| Disease status at alloHCT, n (%) | |
| No CR | 7 (7.7) |
| CR1 | 28 (30.8) |
| CR2 | 54 (59.3) |
| >CR2 | 1 (1) |
| Missing | 1 (1) |
| Relapsed within 2 years (%) in CR1 | 91 (34.5) |
| Non-relapse mortality within 2 years in CR1, n (%) | 15 (5.7) |
| EFS duration, months (median) | 25.5 |
| DFS duration, months (median) | 29.5 |
| OS duration, months (median) | Not reached |
Abbreviations: AlloHCT, allogeneic hematopoietic cell transplantation; CR, complete remission, DFS, disease-free survival; EFS, event-free survival; OS, overall survival; WBC, white blood cell count.