Table 2.
Minimum Inhibitory Concentrations (MICs) of 113 Carbapenem-Nonsusceptible ECC Isolates
| Isolates | MIC (μg/mL) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ATM | CRO | CAZ | FEP | ETP | IPM | MEM | CIP | LVX | GEN | TOB | AMK | SXT | NIT | COL | |
| Y509 | ≤1 | ≥64 | ≥64 | ≥64 | 16 | 2 | 4 | 1 | 1 | ≥16 | ≥16 | 8 | ≥320 | / | 0.25 |
| Y541 | 64 | ≥32 | ≥128 | 32 | 2 | 0.5 | ≤0.125 | 0.06 | 0.06 | 4 | 2 | 4 | ≥320 | 64 | 8 |
| Y542 | 32 | ≥32 | ≥128 | 4 | 2 | 0.5 | 0.25 | 0.25 | 0.06 | 2 | 0.5 | 2 | 20 | 64 | 0.125 |
| Y569 | 32 | ≥32 | ≥128 | 4 | 1 | ≤0.125 | ≤0.125 | 0.06 | 0.06 | 2 | 0.5 | 2 | ≤5 | 32 | 0.125 |
| Y572 | 32 | ≥32 | ≥128 | 1 | 2 | 0.5 | 0.5 | 0.06 | 0.06 | 2 | 2 | 8 | 10 | 32 | 0.25 |
| Y573 | ≥128 | ≥32 | ≥128 | 8 | 2 | 0.5 | 0.25 | ≥8 | ≥16 | 64 | 16 | ≥512 | ≥320 | 128 | 0.25 |
| CG35 | 0.5 | ≥32 | ≥128 | 16 | 2 | 8 | 4 | 0.25 | 0.5 | 8 | 8 | 4 | ≥320 | 32 | 0.125 |
| CG38 | 1 | ≥32 | ≥128 | 32 | 64 | 64 | 64 | 0.5 | 1 | 16 | 8 | 4 | ≥320 | 32 | 0.25 |
| CG64 | 32 | ≥32 | ≥128 | 32 | 8 | 4 | 4 | ≥8 | ≥16 | 4 | 16 | 4 | ≥320 | 32 | 0.25 |
| CG80 | 64 | ≥32 | ≥128 | 8 | 1 | 1 | 0.25 | 1 | 1 | 4 | 4 | 1 | ≥320 | 64 | 0.125 |
| CG85 | 0.5 | 4 | 16 | 0.06 | 4 | 2 | 0.25 | 0.5 | 0.06 | 4 | 4 | 8 | ≤5 | 64 | 0.125 |
| CG98 | 64 | 16 | 8 | 8 | 128 | 8 | 16 | ≥8 | ≥16 | 32 | 4 | 4 | ≥320 | ≥1024 | 0.5 |
| CG175 | 4 | ≥32 | ≥128 | ≥128 | >128 | 64 | 64 | 1 | 1 | 8 | 8 | 4 | ≥320 | 128 | >64 |
| CG371 | ≥128 | ≥32 | ≥128 | 8 | 8 | 2 | 4 | 0.5 | 0.25 | ≥128 | 64 | 16 | ≥320 | 32 | 0.25 |
| CG380 | 64 | ≥32 | ≥128 | 4 | 2 | 0.25 | ≤0.125 | 0.25 | 0.03 | 1 | 0.5 | 2 | 40 | 64 | 0.125 |
| CG389 | ≥128 | ≥32 | 16 | 64 | 2 | 1 | 0.25 | ≥8 | ≥16 | ≥128 | ≥128 | ≥512 | ≥320 | 256 | 0.25 |
| CG417 | 32 | ≥32 | 64 | 2 | 4 | 0.5 | 0.25 | 4 | 8 | 1 | 0.5 | 4 | 80 | 128 | 1 |
| CG586 | ≤1 | ≥64 | ≥64 | ≥64 | 16 | 2 | 4 | 1 | 1 | ≥16 | ≥16 | 8 | ≥320 | 64 | 0.5 |
| CG604 | ≥64 | 32 | ≥64 | 4 | 2 | 0.5 | 0.25 | 2 | 4 | 8 | ≥16 | 16 | ≥320 | 128 | 0.5 |
| CG648 | 16 | 16 | 4 | 4 | 4 | 4 | 4 | ≤0.25 | ≤0.25 | ≤1 | ≤0.25 | ≤0.25 | ≤5 | 32 | >64 |
| CG652 | 32 | ≥32 | ≥128 | 2 | 2 | 0.25 | ≤0.125 | 0.25 | 0.5 | 2 | 1 | 4 | ≤5 | 64 | 0.25 |
| CG662 | 8 | ≥32 | ≥128 | 8 | 2 | 4 | 1 | 0.25 | 0.25 | 64 | 4 | 4 | ≥320 | 16 | 0.5 |
| CG666 | 32 | ≥64 | ≥64 | 4 | 2 | 0.25 | 0.25 | ≤0.25 | ≤0.25 | ≤1 | ≤1 | ≤2 | ≤20 | 32 | 0.25 |
| CG698 | ≤1 | ≥64 | ≥64 | 8 | 2 | 1 | 0.5 | ≤0.25 | 1 | 8 | 4 | ≤2 | ≥320 | 64 | >64 |
| CG709 | 1 | 16 | ≥128 | 2 | 2 | 0.5 | ≤0.125 | 0.5 | 0.25 | 32 | 16 | 2 | ≥320 | 32 | 0.5 |
| CG721 | ≥64 | ≥64 | ≥64 | ≥64 | 2 | 1 | 0.25 | ≥4 | ≥8 | ≤1 | 8 | ≤2 | ≤20 | 256 | 0.5 |
| CG727 | ≥64 | ≥64 | ≥64 | ≤1 | 1 | 0.5 | 0.25 | ≤0.25 | ≤0.25 | ≤1 | ≤1 | ≤2 | ≤20 | 64 | >64 |
| CG737 | ≤1 | 4 | 2 | ≤1 | 4 | 0.5 | ≤0.125 | ≥4 | ≥8 | ≤1 | 8 | ≤2 | ≥320 | 64 | >64 |
| CG741 | ≤1 | 4 | 2 | ≤1 | 4 | 0.25 | ≤0.125 | ≥4 | ≥8 | ≤1 | 8 | ≤2 | ≥320 | 64 | 64 |
| CG745 | ≥128 | ≥32 | ≥128 | 16 | 4 | 0.5 | 1 | ≥8 | ≥16 | 1 | 1 | 2 | ≥320 | 64 | 0.5 |
| CG749 | ≤1 | ≥64 | ≥64 | ≥64 | 128 | 8 | 16 | ≥4 | ≥8 | ≥16 | ≥16 | 4 | ≥320 | 64 | 0.5 |
| CG780 | 8 | ≥32 | 64 | 0.5 | 4 | 0.5 | ≤0.125 | ≥8 | ≥16 | 1 | 1 | 2 | ≥320 | 128 | 0.5 |
| CG804 | ≥128 | ≥32 | ≥128 | 64 | 32 | 4 | 4 | ≥8 | ≥16 | 2 | 1 | 4 | ≥320 | 32 | 0.5 |
| CG815 | ≥64 | ≥64 | 16 | 8 | 16 | 16 | 4 | ≤0.25 | ≤0.25 | ≤1 | ≤1 | ≤2 | ≤20 | 64 | 0.5 |
| CG817 | ≥64 | 32 | 16 | 2 | 8 | 4 | 1 | ≤0.25 | ≤0.25 | ≤1 | ≤1 | ≤2 | ≤20 | 32 | 0.5 |
| CG701 | 2 | ≥64 | 2 | 32 | 2 | 2 | 0.25 | ≤0.25 | 1 | ≥16 | 8 | ≤2 | ≥320 | 32 | >64 |
| CG718 | ≤1 | ≤1 | ≤1 | ≤1 | 0.25 | 4 | ≤0.125 | 0.5 | 1 | ≤1 | ≤1 | ≤2 | ≤20 | 64 | 0.5 |
| CG824 | ≥64 | ≥64 | ≥64 | 2 | 1 | 0.25 | ≤0.125 | ≤0.25 | ≤0.25 | ≤1 | ≤1 | ≤2 | ≤20 | 64 | 0.5 |
| CG848 | ≥64 | ≥64 | ≥64 | 16 | 4 | 0.5 | 0,25 | ≥4 | 4 | ≤1 | ≤1 | ≤2 | ≤20 | 64 | 0.5 |
| CG864 | ≥64 | ≥64 | ≥64 | 4 | 8 | 0.5 | ≤0.125 | ≤0.25 | ≤0.25 | ≤1 | ≤1 | ≤2 | ≤20 | / | >64 |
| CG871 | ≥64 | ≥64 | ≥64 | 2 | 2 | 0.5 | 0.125 | ≤0.25 | 0.5 | ≤1 | ≤1 | ≤2 | ≤20 | / | 0.5 |
| CG884 | ≥64 | ≥64 | ≥64 | ≤1 | 2 | 0.5 | ≤0.125 | ≤0.25 | 1 | ≤1 | ≤1 | ≤2 | ≤20 | / | 32 |
| CG901 | 64 | ≥32 | ≥128 | 64 | 16 | 2 | 2 | ≥8 | 8 | 64 | ≥128 | ≥512 | ≥320 | 256 | 0.5 |
| CG911 | ≥64 | ≥64 | 16 | 16 | 16 | 8 | 4 | 0.5 | 1 | ≥16 | ≥16 | 16 | ≥320 | 64 | 0.5 |
| CG914 | ≥64 | ≥64 | 16 | 16 | 32 | 4 | 4 | 0.5 | 1 | ≥16 | ≥16 | 16 | ≥320 | 64 | 0.5 |
| CG916 | ≥64 | ≥64 | ≥64 | ≥64 | 128 | 16 | 16 | 0.5 | 1 | ≥16 | ≥16 | ≤2 | ≥320 | 64 | 0.5 |
| CG934 | ≥64 | ≥64 | ≥64 | ≤1 | 2 | 0.25 | ≤0.125 | ≤0.25 | ≤0.25 | ≤1 | ≤1 | ≤2 | ≤20 | ≤16 | >64 |
| CG937 | 16 | ≥64 | ≥64 | ≤1 | 2 | 0.5 | ≤0.125 | ≥4 | ≥8 | ≥16 | ≥16 | ≥64 | ≥320 | 256 | 0.5 |
| CG939 | ≥64 | ≥64 | ≥64 | 4 | 1 | 0.5 | ≤0.125 | 1 | 1 | 8 | ≥16 | 16 | ≥320 | 64 | 0.5 |
| CG945 | ≥64 | ≥64 | ≥64 | 16 | 4 | 0.5 | ≤0.125 | 1 | 2 | 8 | ≥16 | 16 | ≥320 | 64 | 0.5 |
| CG947 | ≥64 | ≥64 | ≥64 | 16 | 1 | 0.5 | 0.25 | 1 | 2 | 8 | ≥16 | 16 | ≥320 | 64 | 0.5 |
| CG950 | ≥64 | ≥64 | ≥64 | 4 | 2 | 0.5 | ≤0.125 | 1 | 2 | 8 | ≥16 | 16 | ≥320 | 64 | 0.5 |
| CG952 | ≥64 | ≥64 | ≥64 | 4 | 4 | 0.5 | 0.5 | 1 | 2 | 8 | ≥16 | 16 | ≥320 | 64 | 0.5 |
| CG983 | 16 | ≥64 | ≥64 | ≥64 | 128 | 8 | 16 | ≥4 | ≥8 | ≥16 | ≥16 | ≥64 | ≤20 | 256 | 0.5 |
| CG996 | 4 | ≥64 | ≥64 | 16 | 8 | 2 | 1 | ≤0.25 | ≤0.25 | ≥16 | ≥16 | ≤2 | ≤20 | 64 | 0.5 |
| CG1005 | ≥64 | ≥64 | ≥64 | ≥64 | >256 | 64 | 128 | ≥4 | 4 | ≥16 | ≥16 | 4 | ≥320 | ≥512 | 1 |
| CG1015 | ≥64 | ≥64 | ≥64 | 2 | 1 | 0.25 | ≤0.125 | ≤0.25 | ≤0.25 | ≤1 | ≤1 | ≤2 | ≤20 | 32 | 0.25 |
| CG1038 | ≥64 | ≥64 | 4 | 4 | 2 | 4 | 1 | ≤0.25 | ≤0.25 | ≤1 | ≤1 | ≤2 | ≤20 | 32 | 32 |
| CG1041 | ≥64 | ≥64 | ≥64 | 2 | 1 | 0.25 | ≤0.125 | ≤0.25 | ≤0.25 | ≤1 | ≤1 | ≤2 | ≤20 | 33 | 0.5 |
| CG1045 | ≥64 | ≥64 | ≥64 | ≥64 | 8 | 1 | 2 | ≥4 | ≥8 | 8 | ≥16 | 16 | ≥320 | ≤16 | 0.5 |
| CG1050 | ≥64 | ≥64 | ≥64 | ≤1 | 2 | 0.5 | ≤0.125 | 1 | 1 | ≤1 | ≤1 | ≤2 | ≤20 | 32 | 16 |
| CG1051 | ≥64 | ≥64 | ≥64 | 2 | 4 | 0.25 | ≤0.125 | 1 | 1 | ≤1 | ≤1 | ≤2 | ≤20 | 32 | >64 |
| CG1070 | 2 | 16 | 4 | ≤1 | 16 | 0.5 | 0.25 | ≥4 | 4 | ≤1 | ≤1 | ≤2 | ≤20 | 128 | 0.125 |
| CG1075 | ≥64 | ≥64 | ≥64 | ≥64 | 32 | 2 | 2 | ≥4 | ≥8 | ≥16 | 8 | ≤2 | ≥320 | 64 | 0.25 |
| CG1079 | ≥64 | ≥64 | ≥64 | ≤1 | 4 | 0.5 | 0.5 | ≥4 | 4 | 4 | 2 | 8 | ≤20 | 128 | 0.125 |
| CG1081 | ≥64 | ≥64 | ≥64 | 8 | 8 | 0.25 | 0.25 | ≥4 | ≥8 | ≥16 | ≥16 | ≤2 | ≥320 | 32 | 0.125 |
| CG1090 | ≥64 | ≥64 | ≥64 | ≥64 | 16 | 1 | 4 | ≥4 | ≥8 | ≥16 | 8 | ≤2 | ≥320 | 64 | 0.125 |
| CG1043 | ≤1 | 8 | 4 | ≤1 | 1 | 1 | 0.5 | ≥4 | 2 | ≥16 | 8 | ≤2 | ≥320 | 128 | 0.25 |
| CG1159 | 4 | 32 | 4 | 2 | 4 | 0.25 | ≤0.125 | 1 | 1 | 8 | 4 | ≤2 | ≥320 | 64 | 0.5 |
| CG1181 | ≥64 | ≥64 | ≥64 | ≤1 | 2 | 1 | 0.25 | ≤0.25 | ≤0.25 | ≤1 | ≤1 | ≤2 | ≤20 | 32 | 0.5 |
| CG1208 | ≥64 | ≥64 | ≥64 | 4 | 4 | 0.5 | 0.25 | 2 | 4 | 4 | 4 | ≤2 | ≥320 | 128 | 0.5 |
| CG1212 | ≥64 | ≥64 | ≥64 | 2 | 2 | 0.25 | ≤0.125 | 1 | 1 | ≤1 | ≤1 | ≤2 | ≤20 | 32 | 0.125 |
| CG1231 | ≥64 | ≥64 | ≥64 | 2 | 4 | 0.25 | 0.25 | ≤0.25 | ≤0.25 | ≤1 | ≤1 | ≤2 | ≤20 | 32 | 0.25 |
| CG1236 | 32 | ≥64 | ≥64 | ≤1 | 4 | 1 | 2 | ≤0.25 | ≤0.25 | ≤1 | ≤1 | ≤2 | ≤20 | 32 | 0.25 |
| CG1244 | ≥64 | ≥64 | ≥64 | ≤1 | 2 | 0.25 | 0.5 | ≤0.25 | ≤0.25 | ≤1 | ≤1 | ≤2 | ≤20 | 32 | 0.125 |
| CG1249 | ≥64 | ≥64 | ≥64 | 4 | 16 | 0.5 | 4 | 0.5 | 0.5 | ≤1 | ≤1 | ≤2 | ≤20 | 32 | >64 |
| CG1250 | ≥64 | ≥64 | ≥64 | 8 | 2 | 0.25 | 0.25 | 2 | 1 | ≤1 | ≤1 | ≤2 | ≥320 | 64 | 0.25 |
| CG1252 | 16 | 16 | 16 | ≤1 | 1 | 0.5 | ≤0.125 | ≤0.25 | ≤0.25 | ≤1 | ≤1 | ≤2 | ≤20 | 64 | 0.5 |
| CG1257 | ≤1 | ≥64 | ≥64 | ≥64 | 4 | 8 | 4 | ≤0.25 | 1 | 4 | 8 | ≤2 | ≥320 | 64 | 0.5 |
| CG1280 | ≥64 | ≥64 | ≥64 | 2 | 1 | 0.25 | ≤0.125 | ≤0.25 | ≤0.25 | ≤1 | ≤1 | ≤2 | ≤20 | 64 | 0.125 |
| CG1281 | ≥64 | ≥64 | ≥64 | 2 | 1 | 0.25 | ≤0.125 | ≤0.25 | ≤0.25 | ≤1 | ≤1 | ≤2 | ≤20 | 64 | 0.125 |
| CG1330 | ≥64 | ≥64 | ≥64 | ≥64 | 16 | 4 | 4 | ≥4 | ≥8 | 4 | 4 | ≤2 | ≥320 | 64 | 0.125 |
| CG1376 | 64 | ≥32 | ≥128 | 32 | 16 | 4 | 4 | 1 | 1 | 4 | 16 | 4 | ≥320 | 64 | 0.25 |
| CG1381 | ≥64 | ≥64 | ≥64 | ≥64 | 16 | 16 | 8 | 0.5 | 1 | 4 | 8 | ≤2 | ≥320 | 32 | 0.25 |
| CG1400 | ≥64 | ≥64 | ≥64 | 32 | 2 | 1 | 2 | ≥4 | ≥8 | ≥16 | ≥16 | 4 | ≥320 | 64 | >64 |
| CG1457 | ≥64 | ≥64 | ≥64 | ≥64 | 4 | 0.25 | 0.5 | ≤0.25 | 1 | ≤1 | ≤1 | ≤2 | ≤20 | 64 | 0.5 |
| CG1461 | ≥64 | ≥64 | ≥64 | 16 | 4 | 2 | 1 | ≤0.25 | 1 | ≤1 | ≤1 | ≤2 | ≤20 | 128 | 0.5 |
| CG1144 | ≥128 | 8 | ≥128 | 4 | ≤0.125 | 2 | ≤0.125 | 0.5 | 0.25 | 1 | 1 | 2 | ≤5 | 31 | 0.5 |
| CG1479 | ≥64 | ≥64 | ≥64 | 8 | 128 | 16 | 8 | ≤0.25 | ≤0.25 | ≤1 | ≤1 | ≤2 | ≤20 | 32 | >64 |
| CG1498 | 16 | ≥64 | ≥64 | ≥64 | 4 | 16 | 1 | 2 | 1 | 4 | 8 | ≤2 | ≥320 | 32 | 0.5 |
| CG1506 | ≥64 | ≥64 | ≥64 | 4 | 4 | 8 | 2 | 1 | 1 | ≥16 | ≥16 | 16 | ≤20 | ≤16 | >64 |
| CG1522 | ≥64 | ≥64 | ≥64 | 8 | 4 | 2 | 0.25 | ≤0.25 | ≤0.25 | ≤1 | ≤1 | ≤2 | ≤20 | 256 | 0.5 |
| CG1532 | ≥64 | ≥64 | ≥64 | 4 | 2 | 1 | 0.25 | 0.5 | 1 | 8 | 8 | ≤2 | ≥320 | 64 | 0.5 |
| CG1547 | ≥64 | ≥64 | ≥64 | ≥64 | 16 | 16 | 16 | ≥4 | 4 | ≤1 | ≤1 | 4 | ≥320 | 128 | 0.5 |
| CG1563 | ≥128 | ≥32 | ≥128 | 1 | 2 | 1 | 0.25 | 1 | 1 | 2 | 1 | 2 | ≤5 | 16 | 0.25 |
| CG1565 | ≥64 | ≥64 | ≥64 | 32 | 4 | 0.25 | 0.25 | 2 | 2 | 8 | ≥16 | 32 | ≥320 | 64 | 0.5 |
| CG1574 | 2 | ≥64 | ≥64 | 32 | 8 | 16 | 8 | 1 | 1 | ≤1 | ≤1 | ≤2 | ≤20 | 64 | >64 |
| CG1581 | ≥64 | ≥64 | ≥64 | 32 | 4 | 0.5 | 0.25 | ≥4 | ≥8 | 8 | ≥16 | 16 | ≥320 | 128 | 1 |
| CG1589 | ≥128 | ≥32 | ≥128 | 4 | 2 | 0.5 | 0.25 | ≥8 | ≥16 | ≥128 | ≥128 | ≥512 | ≥320 | 128 | 0.5 |
| CG1591 | ≥64 | ≥64 | ≥64 | ≥64 | 16 | 4 | 4 | ≥4 | ≥8 | ≤4 | ≥16 | ≤16 | ≥320 | ≤16 | 0.25 |
| CG1593 | 32 | ≥64 | ≥64 | ≥16 | 2 | 8 | 2 | 0.5 | 1 | ≤1 | 8 | ≤2 | ≤20 | ≤16 | 0.5 |
| CG1601 | 16 | ≥64 | ≥16 | ≤2 | 1 | 2 | ≤0.125 | 2 | 1 | ≥16 | 8 | ≤2 | ≥320 | 64 | 0.5 |
| CG1606 | ≥64 | ≥64 | ≥64 | ≥64 | 8 | 2 | 1 | ≥4 | ≥8 | ≥16 | ≥16 | ≥64 | ≥320 | 256 | 1 |
| CG1608 | 64 | ≥32 | ≥128 | 16 | 16 | 16 | 8 | 1 | 4 | ≥128 | 8 | 2 | ≤5 | 32 | 0.5 |
| CG1640 | ≥64 | ≥64 | 16 | 8 | >128 | 64 | 64 | ≥4 | 1 | ≤1 | 8 | ≤2 | ≤20 | 32 | 0.5 |
| CG1728 | ≥64 | ≥64 | ≥64 | 4 | 4 | 0.25 | 0.25 | ≤0.25 | ≤0.25 | ≤1 | ≤1 | ≤2 | ≤20 | 64 | 0.5 |
| CG1737 | ≤1 | ≥64 | ≥64 | ≥64 | 64 | 8 | 8 | ≥4 | ≥8 | 8 | ≥16 | ≤2 | ≥320 | 64 | 0.5 |
| CG1746 | ≥128 | ≥32 | 64 | 32 | 4 | 0.5 | ≤0.125 | ≥8 | ≥16 | ≥128 | 32 | 4 | ≥320 | 64 | 0.5 |
| CG1778 | ≤4 | ≥64 | ≥64 | ≥64 | 32 | 8 | 8 | ≥4 | ≥8 | ≤1 | ≤1 | ≤2 | ≥320 | 64 | 0.5 |
| CG1779 | ≤1 | ≥64 | ≥64 | ≥64 | 16 | 8 | 8 | ≥4 | ≥8 | ≤1 | ≤1 | ≤2 | ≥320 | / | 0.5 |
| CG1781 | ≤1 | ≥64 | ≥64 | ≥64 | 16 | 8 | 4 | ≥4 | ≥8 | ≤1 | ≤1 | ≤2 | ≥320 | / | 0.5 |
| CG1813 | 8 | ≥64 | ≥64 | 32 | 16 | 2 | 4 | 1 | 2 | 8 | 8 | ≤2 | ≥320 | / | 0.25 |
| CG1819 | ≤1 | ≥64 | ≥64 | ≥64 | 32 | 4 | 8 | ≤0.25 | ≤0.25 | ≤1 | ≤1 | ≤2 | ≤20 | / | >64 |
Abbreviations: ECC, Enterobacter cloacae complex; ATM, aztreonam; CRO, ceftriaxone; CAZ, ceftazidime; IPM, imipenem; MEM, meropenem; ETP, ertapenem; CIP, ciprofloxacin; LVX, levofloxacin; GEN, gentamicin; TOB, tobramycin; AMK, amikacin; COL, colistin; NIT, nitrofurantoin; SXT, trimethoprim-sulfamethoxazole; FEP, cefepime; /, not available.