Table 3.

Preclinical and Clinical Stroke Studies Assessing the Effect of Different LncRNAs on the Regulation of Autophagy

Author, Year	LncRNA	Models	Species	Regulation	Targets	Main Functions
Yu et al 2019	KCNQ1OT1	tMCAO, OGD/R	Human, Mice, Cells	Up	miR-200a, FOXO3, ATG7	Knockdown inhibits autophagy and increase cell viability
Luo et al 2020	MEG3	MCAO, OGD/R	Mice, Cells	Up	miR-378, Beclin1, LC3	MEG3/miR-378/GRB2 protected against neuronal autophagy
Yao et al 2019	SNHG12	MCAO, OGD/R	Mice, Cells	Up	Beclin1, LC3, p62	Up-regulation of SNHG12 induce autophagy activation
Wu et al 2020	SNHG12	OGD/R	Cells	Up	SIRT1, FOXO3a	Knockdown inhibits SIRT1/FOXO3a signaling-mediated autophagy
Gao et al 2020	LNHG3	tMCAO, OGD/R	Mice, Cells	Up	miR-485, LC3, Beclin1	Knockdown improve brain I/R injury to restrain autophagy
Li et al 2017	MALAT1	OGD/R	Mice, Cells	Up	miR-26b, LC-3, p62	MALAT1 promote BMEC autophagy and survival under OGD/R condition
Wang et al 2019	MALAT1	OGD/R	Cells	Up	miR-300c-3p, p62, LC3	MALAT1 activate autophagy and promoted cell survival under hypoxic condition
Guo et al 2021	MIAT	MCAO, OGD/R	Rats, Cells	Up	LC3, p62	MIAT promote autophagy of neural cells and aggravate ischemic stroke
Xu et al 2021	C2dat2	MCAO, OGD/R	Mice, Cells	Up	miR-30d-5p, LC3, Beclin1, p62	C2dat2/miR-30d-5p/DDIT4/mTOR facilitate autophagy

Abbreviations: LncRNA, long non-coding RNA; MCAO, middle cerebral artery occlusion; tMCAO, transient middle cerebral artery occlusion; OGD/R, oxygen glucose deprivation/re-oxygenation; I/R, ischemia and reperfusion; FOXO3, forkhead box O3; MEG3, maternally expressed gene 3; BMEC, Brain microvascular endothelial cell; CIRI, cerebral ischemia-reperfusion injury.