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. 2021 Sep 12;2021(9):CD011612. doi: 10.1002/14651858.CD011612.pub3

Comparison 1. Ketamine versus Placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1.1 Response rate 12   Odds Ratio (M‐H, Random, 95% CI) Subtotals only
1.1.1 at 24 hours 7 185 Odds Ratio (M‐H, Random, 95% CI) 3.94 [1.54, 10.10]
1.1.2 at 72 hours 4 83 Odds Ratio (M‐H, Random, 95% CI) 15.84 [3.68, 68.12]
1.1.3 at 1 week 5 196 Odds Ratio (M‐H, Random, 95% CI) 3.76 [0.98, 14.42]
1.1.4 at 2 weeks 4 206 Odds Ratio (M‐H, Random, 95% CI) 2.92 [0.48, 17.78]
1.1.5 at 4 weeks 4 202 Odds Ratio (M‐H, Random, 95% CI) 1.37 [0.50, 3.77]
1.1.6 at 3 months 3 117 Odds Ratio (M‐H, Random, 95% CI) 1.95 [0.24, 15.69]
1.2 AE Abdominal Pain 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
1.3 AE Agitation/anxiety 3 143 Odds Ratio (M‐H, Random, 95% CI) 3.44 [1.07, 11.04]
1.4 AE Blurred vision 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
1.5 AE Change in blood pressure 2 157 Odds Ratio (M‐H, Random, 95% CI) 3.23 [0.49, 21.31]
1.6 AE Confusion 2 76 Odds Ratio (M‐H, Random, 95% CI) 3.76 [1.13, 12.47]
1.7 AE Dissociative symptoms 3 145 Odds Ratio (M‐H, Random, 95% CI) 7.72 [1.31, 45.51]
1.8 AE Dizziness 3 196 Odds Ratio (M‐H, Random, 95% CI) 1.74 [0.52, 5.81]
1.9 AE Emotional blunting 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
1.10 AE Euphoria 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
1.11 AE Hallucinations 3 203 Odds Ratio (M‐H, Random, 95% CI) 2.19 [0.45, 10.78]
1.12 AE Headache 2 194 Odds Ratio (M‐H, Random, 95% CI) 1.23 [0.62, 2.45]
1.13 AE Infections and Infestations 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
1.14 AE Loss of Appetite 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
1.15 AE Mania/hypomania 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
1.16 AE Musculoskeletal and connective tissue disorders 2 137 Odds Ratio (M‐H, Random, 95% CI) 1.39 [0.07, 26.35]
1.17 AE Nausea/vomiting 5 353 Odds Ratio (M‐H, Random, 95% CI) 1.83 [0.81, 4.13]
1.18 AE Nervousness 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
1.19 AE Nervous system disorders 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
1.20 AE Palpitations 1   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
1.21 AE Psychiatric disorders 2 137 Odds Ratio (M‐H, Fixed, 95% CI) 0.93 [0.30, 2.93]
1.22 AE Restlessness 1   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
1.23 AE Skin and subcutaneous tissue disorders 1   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
1.24 AE Suicidal Ideas 1   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
1.25 AE Tremor 1   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
1.26 Remission rate 9   Odds Ratio (M‐H, Random, 95% CI) Subtotals only
1.26.1 at 24 hours 3 75 Odds Ratio (M‐H, Random, 95% CI) 5.60 [1.07, 29.46]
1.26.2 at 72 hours 4 83 Odds Ratio (M‐H, Random, 95% CI) 6.60 [1.51, 28.92]
1.26.3 at 1 week 5 196 Odds Ratio (M‐H, Random, 95% CI) 4.64 [1.37, 15.68]
1.26.4 at 2 weeks 4 206 Odds Ratio (M‐H, Random, 95% CI) 1.67 [0.38, 7.27]
1.26.5 at 4 weeks 4 202 Odds Ratio (M‐H, Random, 95% CI) 1.46 [0.54, 3.95]
1.26.6 at 3 months 2 90 Odds Ratio (M‐H, Random, 95% CI) 1.09 [0.45, 2.67]
1.27 Depression rating scale score 12   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
1.27.1 at 24 hours 8 231 Std. Mean Difference (IV, Random, 95% CI) ‐0.87 [‐1.26, ‐0.48]
1.27.2 at 72 hours 6 148 Std. Mean Difference (IV, Random, 95% CI) ‐0.68 [‐1.28, ‐0.07]
1.27.3 at 1 week 6 143 Std. Mean Difference (IV, Random, 95% CI) ‐0.72 [‐1.10, ‐0.33]
1.27.4 at 2 weeks 5 236 Std. Mean Difference (IV, Random, 95% CI) ‐0.43 [‐0.90, 0.04]
1.27.5 at 4 weeks 2 107 Std. Mean Difference (IV, Random, 95% CI) ‐0.68 [‐1.07, ‐0.29]
1.28 Suicidal ideation composite 2   Mean Difference (IV, Random, 95% CI) Subtotals only
1.28.1 at 24 hours 1 48 Mean Difference (IV, Random, 95% CI) 0.02 [‐0.78, 0.82]
1.28.2 at 72 hours 2 68 Mean Difference (IV, Random, 95% CI) 0.34 [‐0.25, 0.93]
1.28.3 at 1 week 1 19 Mean Difference (IV, Random, 95% CI) ‐0.30 [‐1.56, 0.96]
1.28.4 at 2 weeks 1 19 Mean Difference (IV, Random, 95% CI) ‐0.20 [‐1.46, 1.06]
1.29 Cognition scores 1   Mean Difference (IV, Random, 95% CI) Subtotals only
1.29.1 Immediate‐term Memory 1 127 Mean Difference (IV, Random, 95% CI) 0.80 [0.12, 1.48]
1.29.2 Short‐term Memory 1 127 Mean Difference (IV, Random, 95% CI) 6.90 [5.01, 8.79]
1.29.3 Long‐term Memory 1 127 Mean Difference (IV, Random, 95% CI) 4.50 [2.79, 6.21]
1.30 Quality of Life 1   Mean Difference (IV, Random, 95% CI) Subtotals only
1.30.1 EQ‐5D‐3L INDEX at 2 weeks 1 64 Mean Difference (IV, Random, 95% CI) 0.11 [‐0.05, 0.27]
1.31 Acceptability 6 201 Odds Ratio (M‐H, Random, 95% CI) 1.25 [0.19, 8.28]