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. 2021 Sep 12;2021(9):CD011612. doi: 10.1002/14651858.CD011612.pub3

Comparison 9. Esketamine versus placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
9.1 Response rate 7   Odds Ratio (M‐H, Random, 95% CI) Subtotals only
9.1.1 at 24 hours 5 1071 Odds Ratio (M‐H, Random, 95% CI) 2.11 [1.20, 3.68]
9.1.2 at 72 hours 2 451 Odds Ratio (M‐H, Random, 95% CI) 1.34 [0.92, 1.96]
9.1.3 at 1 week 6 1115 Odds Ratio (M‐H, Random, 95% CI) 1.60 [1.09, 2.34]
9.1.4 at 2 weeks 2 451 Odds Ratio (M‐H, Random, 95% CI) 1.57 [1.09, 2.28]
9.1.5 at 4 weeks 5 1117 Odds Ratio (M‐H, Random, 95% CI) 1.84 [1.44, 2.37]
9.2 AE Aggression 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
9.3 AE Agitation/anxiety 4 933 Odds Ratio (M‐H, Random, 95% CI) 1.06 [0.46, 2.42]
9.4 AE Arrhythmia 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
9.5 AE Change in blood pressure 4 933 Odds Ratio (M‐H, Random, 95% CI) 2.67 [1.52, 4.70]
9.6 AE Constipation 2 452 Odds Ratio (M‐H, Random, 95% CI) 4.07 [1.60, 10.39]
9.7 AE Depersonalisation/derealization 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
9.8 AE Depression 2 452 Odds Ratio (M‐H, Random, 95% CI) 0.62 [0.08, 5.05]
9.9 AE Diabetic ketoacidosis 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
9.10 AE Diarrhoea 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
9.11 AE Dissociative symptoms 4 933 Odds Ratio (M‐H, Random, 95% CI) 8.76 [5.19, 14.77]
9.12 AE Dizziness 4 933 Odds Ratio (M‐H, Random, 95% CI) 3.67 [2.54, 5.31]
9.13 AE Dizziness postural 2 569 Odds Ratio (M‐H, Random, 95% CI) 4.70 [1.06, 20.80]
9.14 AE Double vision 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
9.15 AE Euphoria 2 571 Odds Ratio (M‐H, Random, 95% CI) 5.27 [0.94, 29.64]
9.16 AE Fatigue 2 481 Odds Ratio (M‐H, Random, 95% CI) 1.90 [0.89, 4.04]
9.17 AE Feeling drunk 2 571 Odds Ratio (M‐H, Random, 95% CI) 7.58 [1.37, 41.77]
9.18 AE Headache 4 933 Odds Ratio (M‐H, Random, 95% CI) 1.18 [0.80, 1.74]
9.19 AE Hypertransaminasemia 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
9.20 AE Increased sweating 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
9.21 AE Infections and Infestations 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
9.22 AE Insomnia 4 933 Odds Ratio (M‐H, Random, 95% CI) 0.87 [0.53, 1.42]
9.23 AE Lethargy 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
9.24 AE Mental impairment 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
9.25 AE Nasal discomfort 2 571 Odds Ratio (M‐H, Random, 95% CI) 0.84 [0.42, 1.68]
9.26 AE Nausea/vomiting 4 933 Odds Ratio (M‐H, Random, 95% CI) 3.24 [1.84, 5.72]
9.27 AE Paresthesia/neuropathy exacerbation 3 708 Odds Ratio (M‐H, Random, 95% CI) 3.51 [1.62, 7.62]
9.28 AE Pericardial effusion 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
9.29 AE Pneumothorax 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
9.30 AE Sensory disturbance 3 796 Odds Ratio (M‐H, Random, 95% CI) 7.25 [3.55, 14.78]
9.31 AE Sedation 3 796 Odds Ratio (M‐H, Random, 95% CI) 5.31 [2.18, 12.94]
9.32 AE Sleepiness/drowsiness 3 796 Odds Ratio (M‐H, Random, 95% CI) 2.11 [1.39, 3.21]
9.33 AE Sore throat 2 571 Odds Ratio (M‐H, Random, 95% CI) 1.65 [0.70, 3.87]
9.34 AE Suicide attempt 2 452 Odds Ratio (M‐H, Random, 95% CI) 0.99 [0.24, 4.02]
9.35 AE Suicidal ideas 3 796 Odds Ratio (M‐H, Random, 95% CI) 0.69 [0.38, 1.26]
9.36 AE Taste perversion 4 933 Odds Ratio (M‐H, Random, 95% CI) 1.39 [0.95, 2.04]
9.37 AE Tremor 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
9.38 AE Urination issues 1   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
9.39 AE Vertigo 3 796 Odds Ratio (M‐H, Random, 95% CI) 12.25 [4.09, 36.67]
9.40 AE Vision blurred 3 796 Odds Ratio (M‐H, Random, 95% CI) 3.02 [1.37, 6.66]
9.41 Remission rate 7   Odds Ratio (M‐H, Random, 95% CI) Subtotals only
9.41.1 at 24 hours 5 894 Odds Ratio (M‐H, Random, 95% CI) 2.74 [1.71, 4.40]
9.41.2 at 72 hours 3 517 Odds Ratio (M‐H, Random, 95% CI) 1.55 [0.91, 2.64]
9.41.3 at 1 week 6 948 Odds Ratio (M‐H, Random, 95% CI) 1.54 [0.88, 2.69]
9.41.4 at 2 weeks 4 832 Odds Ratio (M‐H, Random, 95% CI) 1.52 [1.07, 2.16]
9.41.5 at 4 weeks 5 957 Odds Ratio (M‐H, Random, 95% CI) 1.57 [1.18, 2.10]
9.42 Depression rating scale score 7   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
9.42.1 at 24 hours 4 824 Std. Mean Difference (IV, Random, 95% CI) ‐0.31 [‐0.45, ‐0.17]
9.42.2 at 72 hours 3 517 Std. Mean Difference (IV, Random, 95% CI) ‐0.30 [‐0.50, ‐0.11]
9.42.3 at 1 week 5 884 Std. Mean Difference (IV, Random, 95% CI) ‐0.23 [‐0.37, ‐0.10]
9.42.4 at 2 weeks 4 857 Std. Mean Difference (IV, Random, 95% CI) ‐0.21 [‐0.34, ‐0.07]
9.42.5 at 4 weeks 6 1182 Std. Mean Difference (IV, Random, 95% CI) ‐0.27 [‐0.39, ‐0.16]
9.42.6 at 3 months 1 38 Std. Mean Difference (IV, Random, 95% CI) ‐0.12 [‐0.75, 0.52]
9.43 Suicidal ideation composite 3   Mean Difference (IV, Random, 95% CI) Subtotals only
9.43.1 at 24 hours 2 450 Mean Difference (IV, Random, 95% CI) ‐0.15 [‐0.44, 0.15]
9.43.2 at 72 hours 2 451 Mean Difference (IV, Random, 95% CI) ‐0.20 [‐0.49, 0.08]
9.43.3 at 1 week 3 660 Mean Difference (IV, Random, 95% CI) 0.01 [‐0.10, 0.13]
9.43.4 at 2 weeks 3 659 Mean Difference (IV, Random, 95% CI) ‐0.10 [‐0.22, 0.02]
9.43.5 at 4 weeks 3 647 Mean Difference (IV, Random, 95% CI) ‐0.04 [‐0.12, 0.05]
9.44 Acceptability 5 773 Odds Ratio (M‐H, Random, 95% CI) 1.58 [0.92, 2.73]