Comparison 11. Lanicemine (AZD6765) versus Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
11.1 Response rate	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
11.1.1 at 24 hours	1	22	Odds Ratio (M‐H, Random, 95% CI)	7.74 [0.35, 170.10]
11.1.2 at 72 hours	1	22	Odds Ratio (M‐H, Random, 95% CI)	2.74 [0.10, 74.87]
11.1.3 at 1 week	1	22	Odds Ratio (M‐H, Random, 95% CI)	2.74 [0.10, 74.87]
11.1.4 at 4 weeks	1	298	Odds Ratio (M‐H, Random, 95% CI)	1.03 [0.63, 1.69]
11.2 AE Agitation/anxiety	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
11.3 AE Back pain	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
11.4 AE Blood Pressure Rise	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
11.5 AE Dissociative symptoms	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
11.6 AE Dizziness	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
11.7 AE Dry mouth	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
11.8 AE Feeling drunk	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
11.9 AE Insomnia	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
11.10 AE Muscle/bone/joint pain	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
11.11 AE Nausea	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
11.12 AE Rash	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
11.13 AE Sedation	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
11.14 AE Upper respiratory infection symptoms	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
11.15 AE Vomiting	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
11.16 AE Weight gain	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
11.17 Remission rate	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
11.17.1 at 24 hours	1	22	Odds Ratio (M‐H, Random, 95% CI)	5.00 [0.21, 117.21]
11.17.2 at 72 hours	1	22	Odds Ratio (M‐H, Random, 95% CI)	2.74 [0.10, 74.87]
11.17.3 at 1 week	1	22	Odds Ratio (M‐H, Random, 95% CI)	2.74 [0.10, 74.87]
11.17.4 at 4 weeks	1	298	Odds Ratio (M‐H, Random, 95% CI)	1.38 [0.75, 2.52]
11.18 Depression rating scale score	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
11.18.1 at 24 hours	1	22	Mean Difference (IV, Random, 95% CI)	‐8.65 [‐17.81, 0.51]
11.18.2 at 72 hours	1	21	Mean Difference (IV, Random, 95% CI)	‐6.27 [‐13.93, 1.39]
11.18.3 at 1 week	1	21	Mean Difference (IV, Random, 95% CI)	‐6.55 [‐14.07, 0.97]
11.18.4 at 4 weeks	1	298	Mean Difference (IV, Random, 95% CI)	‐0.11 [‐1.42, 1.20]
11.18.5 at 3 months	1	298	Mean Difference (IV, Random, 95% CI)	0.51 [‐1.05, 2.07]
11.19 Acceptability	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected