Comparison 12. Org 26576 versus Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
12.1 Response rate	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
12.1.1 at 24 hours	2	54	Odds Ratio (M‐H, Random, 95% CI)	0.81 [0.09, 7.13]
12.1.2 at 72 hours	2	54	Odds Ratio (M‐H, Random, 95% CI)	0.80 [0.16, 3.90]
12.1.3 at 1 week	2	54	Odds Ratio (M‐H, Random, 95% CI)	1.40 [0.31, 6.28]
12.1.4 at 2 weeks	2	54	Odds Ratio (M‐H, Random, 95% CI)	2.24 [0.61, 8.22]
12.1.5 at 4 weeks	1	30	Odds Ratio (M‐H, Random, 95% CI)	0.82 [0.18, 3.74]
12.2 AE Abnormal dreams	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
12.3 AE Back pain	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
12.4 AE Disturbance in attention	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
12.5 AE Dizziness	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
12.6 AE Fatigue	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
12.7 AE Feeling drunk	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
12.8 AE Headache	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
12.9 AE Insomnia	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
12.10 AE Irritability	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
12.11 AE Muscle twitching	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
12.12 AE Nasal congestion	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
12.13 AE Nausea	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
12.14 AE Palpitations	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
12.15 AE Post‐lumbar puncture syndrome	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
12.16 AE Rash	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
12.17 AE Sedation	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
12.18 AE Sensory disturbance	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
12.19 AE Sleepiness/drowsiness	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
12.20 AE Total	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
12.21 Remission rate	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
12.21.1 at 72 hours	2	54	Odds Ratio (M‐H, Random, 95% CI)	0.47 [0.03, 8.60]
12.21.2 at 1 week	2	54	Odds Ratio (M‐H, Random, 95% CI)	1.52 [0.21, 11.06]
12.21.3 at 2 weeks	2	54	Odds Ratio (M‐H, Random, 95% CI)	2.29 [0.43, 12.15]
12.21.4 at 4 weeks	1	30	Odds Ratio (M‐H, Random, 95% CI)	0.64 [0.13, 3.14]
12.22 Depression rating scale score	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
12.22.1 at 24 hours	2	54	Mean Difference (IV, Random, 95% CI)	‐0.51 [‐4.14, 3.13]
12.22.2 at 72 hours	2	54	Mean Difference (IV, Random, 95% CI)	‐0.88 [‐4.67, 2.91]
12.22.3 at 1 week	2	54	Mean Difference (IV, Random, 95% CI)	‐1.43 [‐5.31, 2.44]
12.22.4 at 2 weeks	2	54	Mean Difference (IV, Random, 95% CI)	‐2.61 [‐7.32, 2.09]
12.22.5 at 4 weeks	1	30	Mean Difference (IV, Random, 95% CI)	‐1.25 [‐8.14, 5.64]
12.23 Acceptability ‐ adverse events	2		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only