Comparison 19. Decoglurant (mGlu2/3) versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
19.1 Response Rate	1	309	Odds Ratio (M‐H, Random, 95% CI)	2.04 [1.23, 3.38]
19.1.1 at 4 weeks	1	309	Odds Ratio (M‐H, Random, 95% CI)	2.04 [1.23, 3.38]
19.2 AE Diarrhea	1	357	Odds Ratio (M‐H, Random, 95% CI)	0.91 [0.42, 1.99]
19.3 AE Dizziness	1	357	Odds Ratio (M‐H, Random, 95% CI)	2.01 [1.03, 3.94]
19.4 AE Headache	1	357	Odds Ratio (M‐H, Random, 95% CI)	1.02 [0.61, 1.70]
19.5 AE Nausea	1	357	Odds Ratio (M‐H, Random, 95% CI)	1.38 [0.74, 2.59]
19.6 AE Sleepiness/drowsiness	1	357	Odds Ratio (M‐H, Random, 95% CI)	4.78 [0.61, 37.26]
19.7 AE Vomiting	1	357	Odds Ratio (M‐H, Random, 95% CI)	2.11 [0.79, 5.65]
19.8 Remission rate	1	309	Odds Ratio (M‐H, Random, 95% CI)	1.60 [0.95, 2.69]
19.8.1 at 4 weeks	1	309	Odds Ratio (M‐H, Random, 95% CI)	1.60 [0.95, 2.69]