Skip to main content
. 2021 Sep 12;2021(9):CD011612. doi: 10.1002/14651858.CD011612.pub3

Comparison 23. Ketamine versus Placebo (pre‐planned subgroup analysis: outpatient treatment setting).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
23.1 Response rate 3   Odds Ratio (M‐H, Random, 95% CI) Subtotals only
23.1.1 at 24 hours 1 27 Odds Ratio (M‐H, Random, 95% CI) 18.76 [0.92, 383.10]
23.1.2 at 72 hours 1 27 Odds Ratio (M‐H, Random, 95% CI) 33.46 [1.65, 677.83]
23.1.3 at 1 week 1 27 Odds Ratio (M‐H, Random, 95% CI) 33.46 [1.65, 677.83]
23.1.4 at 2 weeks 1 27 Odds Ratio (M‐H, Random, 95% CI) 20.80 [2.04, 211.79]
23.1.5 at 4 weeks 3 132 Odds Ratio (M‐H, Random, 95% CI) 2.00 [0.68, 5.85]
23.1.6 at 3 months 2 47 Odds Ratio (M‐H, Random, 95% CI) 3.95 [0.16, 97.23]
23.2 Remission rate 4   Odds Ratio (M‐H, Random, 95% CI) Subtotals only
23.2.1 at 24 hours 1 27 Odds Ratio (M‐H, Random, 95% CI) 3.48 [0.13, 93.30]
23.2.2 at 72 hours 1 27 Odds Ratio (M‐H, Random, 95% CI) 6.30 [0.27, 144.70]
23.2.3 at 1 week 1 27 Odds Ratio (M‐H, Random, 95% CI) 6.30 [0.27, 144.70]
23.2.4 at 2 weeks 1 27 Odds Ratio (M‐H, Random, 95% CI) 3.90 [0.35, 43.36]
23.2.5 at 4 weeks 3 132 Odds Ratio (M‐H, Random, 95% CI) 2.19 [0.85, 5.66]
23.2.6 at 3 months 2 90 Odds Ratio (M‐H, Random, 95% CI) 1.09 [0.45, 2.67]
23.3 Depression rating scale score 4   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
23.3.1 at 24 hours 2 75 Std. Mean Difference (IV, Random, 95% CI) ‐0.47 [‐1.11, 0.18]
23.3.2 at 72 hours 3 94 Std. Mean Difference (IV, Random, 95% CI) ‐0.28 [‐1.18, 0.62]
23.3.3 at 1 week 2 45 Std. Mean Difference (IV, Random, 95% CI) ‐0.52 [‐1.69, 0.65]
23.3.4 at 2 weeks 3 126 Std. Mean Difference (IV, Random, 95% CI) ‐0.73 [‐1.31, ‐0.15]
23.3.5 at 4 weeks 2 107 Std. Mean Difference (IV, Random, 95% CI) ‐0.68 [‐1.07, ‐0.29]
23.4 Suicidal ideation composite 2   Mean Difference (IV, Random, 95% CI) Subtotals only
23.4.1 at 24 hours 1 48 Mean Difference (IV, Random, 95% CI) 0.02 [‐0.78, 0.82]
23.4.2 at 72 hours 2 68 Mean Difference (IV, Random, 95% CI) 0.34 [‐0.25, 0.93]
23.4.3 at 1 week 1 19 Mean Difference (IV, Random, 95% CI) ‐0.30 [‐1.56, 0.96]
23.4.4 at 2 weeks 1 19 Mean Difference (IV, Random, 95% CI) ‐0.20 [‐1.46, 1.06]