Comparison 24. Ketamine versus Placebo (pre‐planned subgroup analysis: inpatient treatment setting).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
24.1 Response rate	3		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
24.1.1 at 24 hours	2	48	Odds Ratio (M‐H, Random, 95% CI)	15.11 [1.97, 115.92]
24.1.2 at 72 hours	2	48	Odds Ratio (M‐H, Random, 95% CI)	14.00 [2.07, 94.75]
24.1.3 at 1 week	3	99	Odds Ratio (M‐H, Random, 95% CI)	3.41 [0.95, 12.27]
24.1.4 at 2 weeks	1	51	Odds Ratio (M‐H, Random, 95% CI)	0.93 [0.31, 2.83]
24.2 Remission rate	3		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
24.2.1 at 24 hours	2	48	Odds Ratio (M‐H, Random, 95% CI)	6.60 [0.96, 45.09]
24.2.2 at 72 hours	2	48	Odds Ratio (M‐H, Random, 95% CI)	7.88 [1.17, 53.21]
24.2.3 at 1 week	3	99	Odds Ratio (M‐H, Random, 95% CI)	7.24 [1.70, 30.81]
24.2.4 at 2 weeks	1	51	Odds Ratio (M‐H, Random, 95% CI)	0.95 [0.28, 3.24]
24.3 Depression rating scale score	3		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
24.3.1 at 24 hours	2	46	Std. Mean Difference (IV, Random, 95% CI)	‐1.63 [‐2.86, ‐0.39]
24.3.2 at 72 hours	2	46	Std. Mean Difference (IV, Random, 95% CI)	‐1.21 [‐1.87, ‐0.55]
24.3.3 at 1 week	3	91	Std. Mean Difference (IV, Random, 95% CI)	‐0.75 [‐1.19, ‐0.31]
24.3.4 at 2 weeks	1	46	Std. Mean Difference (IV, Random, 95% CI)	‐0.10 [‐0.68, 0.48]