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. 2021 Sep 12;2021(9):CD011612. doi: 10.1002/14651858.CD011612.pub3

Comparison 26. Esketamine versus placebo (pre‐planned subgroup analysis: inpatient treatment setting).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
26.1 Response rate 1   Odds Ratio (M‐H, Random, 95% CI) Subtotals only
26.1.1 at 24 hours 1 224 Odds Ratio (M‐H, Random, 95% CI) 1.40 [0.79, 2.49]
26.1.2 at 72 hours 1 224 Odds Ratio (M‐H, Random, 95% CI) 1.52 [0.88, 2.62]
26.1.3 at 1 week 1 224 Odds Ratio (M‐H, Random, 95% CI) 1.29 [0.76, 2.18]
26.1.4 at 2 weeks 1 224 Odds Ratio (M‐H, Random, 95% CI) 1.71 [1.01, 2.91]
26.1.5 at 4 weeks 1 224 Odds Ratio (M‐H, Random, 95% CI) 1.85 [1.09, 3.14]
26.2 Remission rate 2   Odds Ratio (M‐H, Random, 95% CI) Subtotals only
26.2.1 at 24 hours 2 290 Odds Ratio (M‐H, Random, 95% CI) 2.25 [1.13, 4.49]
26.2.2 at 72 hours 2 290 Odds Ratio (M‐H, Random, 95% CI) 1.61 [0.59, 4.34]
26.2.3 at 1 week 2 290 Odds Ratio (M‐H, Random, 95% CI) 1.22 [0.70, 2.13]
26.2.4 at 2 weeks 2 290 Odds Ratio (M‐H, Random, 95% CI) 1.39 [0.83, 2.32]
26.2.5 at 4 weeks 2 290 Odds Ratio (M‐H, Random, 95% CI) 1.48 [0.91, 2.42]
26.3 Depression rating scale score 2   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
26.3.1 at 24 hours 2 290 Std. Mean Difference (IV, Random, 95% CI) ‐0.35 [‐0.58, ‐0.12]
26.3.2 at 72 hours 2 290 Std. Mean Difference (IV, Random, 95% CI) ‐0.41 [‐0.64, ‐0.17]
26.3.3 at 1 week 2 290 Std. Mean Difference (IV, Random, 95% CI) ‐0.20 [‐0.43, 0.04]
26.3.4 at 2 weeks 2 290 Std. Mean Difference (IV, Random, 95% CI) ‐0.14 [‐0.37, 0.09]
26.3.5 at 4 weeks 2 290 Std. Mean Difference (IV, Random, 95% CI) ‐0.25 [‐0.48, ‐0.02]
26.4 Suicidal ideation composite 1   Mean Difference (IV, Random, 95% CI) Subtotals only
26.4.1 at 24 hours 1 224 Mean Difference (IV, Random, 95% CI) ‐0.20 [‐0.63, 0.23]
26.4.2 at 72 hours 1 224 Mean Difference (IV, Random, 95% CI) ‐0.30 [‐0.69, 0.09]
26.4.3 at 1 week 1 224 Mean Difference (IV, Random, 95% CI) ‐0.20 [‐0.56, 0.16]
26.4.4 at 2 weeks 1 224 Mean Difference (IV, Random, 95% CI) ‐0.10 [‐0.43, 0.23]
26.4.5 at 4 weeks 1 224 Mean Difference (IV, Random, 95% CI) ‐0.20 [‐0.53, 0.13]