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. 2021 Sep 12;2021(9):CD011612. doi: 10.1002/14651858.CD011612.pub3

Comparison 28. Ketamine versus Placebo (pre‐planned sensitivity analysis: excluding studies that included participants with bipolar disorder or psychotic features).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
28.1 Response rate 9   Odds Ratio (M‐H, Random, 95% CI) Subtotals only
28.1.1 at 24 hours 6 177 Odds Ratio (M‐H, Random, 95% CI) 4.33 [1.47, 12.80]
28.1.2 at 72 hours 3 75 Odds Ratio (M‐H, Random, 95% CI) 17.99 [3.58, 90.34]
28.1.3 at 1 week 3 75 Odds Ratio (M‐H, Random, 95% CI) 14.32 [2.90, 70.64]
28.1.4 at 2 weeks 2 85 Odds Ratio (M‐H, Random, 95% CI) 15.73 [4.71, 52.51]
28.1.5 at 4 weeks 3 132 Odds Ratio (M‐H, Random, 95% CI) 2.00 [0.68, 5.85]
28.1.6 at 3 months 2 47 Odds Ratio (M‐H, Random, 95% CI) 3.95 [0.16, 97.23]
28.2 Remission rate 6   Odds Ratio (M‐H, Random, 95% CI) Subtotals only
28.2.1 at 24 hours 3 75 Odds Ratio (M‐H, Random, 95% CI) 5.60 [1.07, 29.46]
28.2.2 at 72 hours 3 75 Odds Ratio (M‐H, Random, 95% CI) 7.42 [1.45, 37.89]
28.2.3 at 1 week 3 75 Odds Ratio (M‐H, Random, 95% CI) 9.02 [1.80, 45.31]
28.2.4 at 2 weeks 2 85 Odds Ratio (M‐H, Random, 95% CI) 7.50 [1.51, 37.22]
28.2.5 at 4 weeks 3 132 Odds Ratio (M‐H, Random, 95% CI) 2.19 [0.85, 5.66]
28.2.6 at 3 months 1 20 Odds Ratio (M‐H, Random, 95% CI) 1.29 [0.14, 11.54]
28.3 Depression rating scale score 9   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
28.3.1 at 24 hours 7 223 Std. Mean Difference (IV, Random, 95% CI) ‐0.88 [‐1.31, ‐0.46]
28.3.2 at 72 hours 5 140 Std. Mean Difference (IV, Random, 95% CI) ‐0.63 [‐1.29, 0.04]
28.3.3 at 1 week 4 90 Std. Mean Difference (IV, Random, 95% CI) ‐0.76 [‐1.34, ‐0.19]
28.3.4 at 2 weeks 3 126 Std. Mean Difference (IV, Random, 95% CI) ‐0.73 [‐1.31, ‐0.15]
28.3.5 at 4 weeks 2 107 Std. Mean Difference (IV, Random, 95% CI) ‐0.68 [‐1.07, ‐0.29]
28.4 Suicidal ideation composite 2   Mean Difference (IV, Random, 95% CI) Subtotals only
28.4.1 at 24 hours 1 48 Mean Difference (IV, Random, 95% CI) 0.02 [‐0.78, 0.82]
28.4.2 at 72 hours 2 68 Mean Difference (IV, Random, 95% CI) 0.34 [‐0.25, 0.93]
28.4.3 at 1 week 1 19 Mean Difference (IV, Random, 95% CI) ‐0.30 [‐1.56, 0.96]
28.4.4 at 2 weeks 1 19 Mean Difference (IV, Random, 95% CI) ‐0.20 [‐1.46, 1.06]