Comparison 29. Ketamine versus Placebo (pre‐planned sensitivity analysis: excluding TRD populations).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
29.1 Response rate	4		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
29.1.1 at 24 hours	3	68	Odds Ratio (M‐H, Random, 95% CI)	2.31 [0.65, 8.14]
29.1.2 at 72 hours	2	38	Odds Ratio (M‐H, Random, 95% CI)	15.32 [1.58, 148.09]
29.1.3 at 1 week	1	30	Odds Ratio (M‐H, Random, 95% CI)	10.29 [0.97, 108.81]
29.1.4 at 4 weeks	1	81	Odds Ratio (M‐H, Random, 95% CI)	4.31 [1.48, 12.56]
29.2 Remission rate	3		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
29.2.1 at 24 hours	1	30	Odds Ratio (M‐H, Random, 95% CI)	6.75 [0.61, 75.27]
29.2.2 at 72 hours	2	38	Odds Ratio (M‐H, Random, 95% CI)	5.63 [0.77, 40.99]
29.2.3 at 1 week	1	30	Odds Ratio (M‐H, Random, 95% CI)	10.29 [0.97, 108.81]
29.2.4 at 4 weeks	1	81	Odds Ratio (M‐H, Random, 95% CI)	1.59 [0.51, 4.98]
29.3 Depression rating scale score	4		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
29.3.1 at 24 hours	3	66	Std. Mean Difference (IV, Random, 95% CI)	‐1.06 [‐1.61, ‐0.52]
29.3.2 at 72 hours	2	36	Std. Mean Difference (IV, Random, 95% CI)	‐1.20 [‐1.96, ‐0.44]
29.3.3 at 1 week	2	35	Std. Mean Difference (IV, Random, 95% CI)	‐1.19 [‐1.97, ‐0.42]
29.3.4 at 2 weeks	1	81	Std. Mean Difference (IV, Random, 95% CI)	‐0.90 [‐1.36, ‐0.45]
29.3.5 at 4 weeks	1	81	Std. Mean Difference (IV, Random, 95% CI)	‐0.77 [‐1.22, ‐0.31]