Comparison 31. Ketamine versus Placebo (post‐hoc sensitivity analysis: excluding multiple doses).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
31.1 Response rate	7		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
31.1.1 at 24 hours	7	185	Odds Ratio (M‐H, Random, 95% CI)	3.94 [1.54, 10.10]
31.1.2 at 72 hours	4	83	Odds Ratio (M‐H, Random, 95% CI)	15.84 [3.68, 68.12]
31.1.3 at 1 week	3	75	Odds Ratio (M‐H, Random, 95% CI)	14.32 [2.90, 70.64]
31.1.4 at 2 weeks	1	27	Odds Ratio (M‐H, Random, 95% CI)	20.80 [2.04, 211.79]
31.1.5 at 4 weeks	1	27	Odds Ratio (M‐H, Random, 95% CI)	1.60 [0.35, 7.40]
31.1.6 at 3 months	1	27	Odds Ratio (M‐H, Random, 95% CI)	20.00 [2.77, 144.31]
31.2 Remission rate	5		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
31.2.1 at 24 hours	3	75	Odds Ratio (M‐H, Random, 95% CI)	5.60 [1.07, 29.46]
31.2.2 at 72 hours	4	83	Odds Ratio (M‐H, Random, 95% CI)	6.60 [1.51, 28.92]
31.2.3 at 1 week	3	75	Odds Ratio (M‐H, Random, 95% CI)	9.02 [1.80, 45.31]
31.2.4 at 2 weeks	2	78	Odds Ratio (M‐H, Random, 95% CI)	1.30 [0.41, 4.12]
31.2.5 at 4 weeks	1	27	Odds Ratio (M‐H, Random, 95% CI)	8.12 [0.80, 82.73]
31.3 Depression rating scale score	9		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
31.3.1 at 24 hours	8	231	Std. Mean Difference (IV, Random, 95% CI)	‐0.87 [‐1.26, ‐0.48]
31.3.2 at 72 hours	6	148	Std. Mean Difference (IV, Random, 95% CI)	‐0.68 [‐1.28, ‐0.07]
31.3.3 at 1 week	4	78	Std. Mean Difference (IV, Random, 95% CI)	‐1.07 [‐1.57, ‐0.58]
31.3.4 at 2 weeks	1	26	Std. Mean Difference (IV, Random, 95% CI)	‐1.14 [‐1.98, ‐0.30]
31.3.5 at 4 weeks	1	26	Std. Mean Difference (IV, Random, 95% CI)	‐0.43 [‐1.21, 0.35]
31.4 Suicidal ideation composite	1	96	Mean Difference (IV, Random, 95% CI)	0.06 [‐0.48, 0.59]
31.4.1 at 24 hours	1	48	Mean Difference (IV, Random, 95% CI)	0.02 [‐0.78, 0.82]
31.4.2 at 72 hours	1	48	Mean Difference (IV, Random, 95% CI)	0.09 [‐0.63, 0.81]