Comparison 32. Ketamine versus Placebo (post‐hoc sensitivity analysis: excluding add‐on ECT studies).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
32.1 Response rate	10		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
32.1.1 at 24 hours	7	185	Odds Ratio (M‐H, Random, 95% CI)	3.94 [1.54, 10.10]
32.1.2 at 72 hours	4	83	Odds Ratio (M‐H, Random, 95% CI)	15.84 [3.68, 68.12]
32.1.3 at 1 week	3	75	Odds Ratio (M‐H, Random, 95% CI)	14.32 [2.90, 70.64]
32.1.4 at 2 weeks	2	85	Odds Ratio (M‐H, Random, 95% CI)	15.73 [4.71, 52.51]
32.1.5 at 4 weeks	3	132	Odds Ratio (M‐H, Random, 95% CI)	2.00 [0.68, 5.85]
32.1.6 at 3 months	2	47	Odds Ratio (M‐H, Random, 95% CI)	3.95 [0.16, 97.23]
32.2 Remission rate	7		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
32.2.1 at 24 hours	3	75	Odds Ratio (M‐H, Random, 95% CI)	5.60 [1.07, 29.46]
32.2.2 at 72 hours	4	83	Odds Ratio (M‐H, Random, 95% CI)	6.60 [1.51, 28.92]
32.2.3 at 1 week	3	75	Odds Ratio (M‐H, Random, 95% CI)	9.02 [1.80, 45.31]
32.2.4 at 2 weeks	2	85	Odds Ratio (M‐H, Random, 95% CI)	7.50 [1.51, 37.22]
32.2.5 at 4 weeks	3	132	Odds Ratio (M‐H, Random, 95% CI)	2.19 [0.85, 5.66]
32.2.6 at 3 months	1	20	Odds Ratio (M‐H, Random, 95% CI)	1.29 [0.14, 11.54]
32.3 Depression rating scale score	10		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
32.3.1 at 24 hours	8	231	Std. Mean Difference (IV, Random, 95% CI)	‐0.87 [‐1.26, ‐0.48]
32.3.2 at 72 hours	6	148	Std. Mean Difference (IV, Random, 95% CI)	‐0.68 [‐1.28, ‐0.07]
32.3.3 at 1 week	5	97	Std. Mean Difference (IV, Random, 95% CI)	‐0.80 [‐1.31, ‐0.30]
32.3.4 at 2 weeks	3	126	Std. Mean Difference (IV, Random, 95% CI)	‐0.73 [‐1.31, ‐0.15]
32.3.5 at 4 weeks	2	107	Std. Mean Difference (IV, Random, 95% CI)	‐0.68 [‐1.07, ‐0.29]
32.4 Suicidal ideation composite	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
32.4.1 at 24 hours	1	48	Mean Difference (IV, Random, 95% CI)	0.02 [‐0.78, 0.82]
32.4.2 at 72 hours	2	68	Mean Difference (IV, Random, 95% CI)	0.34 [‐0.25, 0.93]
32.4.3 at 1 week	1	19	Mean Difference (IV, Random, 95% CI)	‐0.30 [‐1.56, 0.96]
32.4.4 at 2 weeks	1	19	Mean Difference (IV, Random, 95% CI)	‐0.20 [‐1.46, 1.06]