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. 2021 Sep 12;2021(9):CD011612. doi: 10.1002/14651858.CD011612.pub3

Comparison 33. Esketamine versus placebo (pre‐planned sensitivity analysis: excluding studies that included participants with bipolar disorder or psychotic features).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
33.1 Response rate 6   Odds Ratio (M‐H, Random, 95% CI) Subtotals only
33.1.1 at 24 hours 5 1071 Odds Ratio (M‐H, Random, 95% CI) 2.11 [1.20, 3.68]
33.1.2 at 72 hours 2 451 Odds Ratio (M‐H, Random, 95% CI) 1.34 [0.92, 1.96]
33.1.3 at 1 week 5 1083 Odds Ratio (M‐H, Random, 95% CI) 1.64 [1.05, 2.54]
33.1.4 at 2 weeks 2 451 Odds Ratio (M‐H, Random, 95% CI) 1.57 [1.09, 2.28]
33.1.5 at 4 weeks 5 1117 Odds Ratio (M‐H, Random, 95% CI) 1.84 [1.44, 2.37]
33.2 Remission rate 6   Odds Ratio (M‐H, Random, 95% CI) Subtotals only
33.2.1 at 24 hours 5 894 Odds Ratio (M‐H, Random, 95% CI) 2.74 [1.71, 4.40]
33.2.2 at 72 hours 3 517 Odds Ratio (M‐H, Random, 95% CI) 1.55 [0.91, 2.64]
33.2.3 at 1 week 5 916 Odds Ratio (M‐H, Random, 95% CI) 1.62 [0.91, 2.89]
33.2.4 at 2 weeks 4 832 Odds Ratio (M‐H, Random, 95% CI) 1.52 [1.07, 2.16]
33.2.5 at 4 weeks 5 957 Odds Ratio (M‐H, Random, 95% CI) 1.57 [1.18, 2.10]
33.3 Depression rating scale score 6   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
33.3.1 at 24 hours 4 824 Std. Mean Difference (IV, Random, 95% CI) ‐0.31 [‐0.45, ‐0.17]
33.3.2 at 72 hours 3 517 Std. Mean Difference (IV, Random, 95% CI) ‐0.30 [‐0.50, ‐0.11]
33.3.3 at 1 week 4 857 Std. Mean Difference (IV, Random, 95% CI) ‐0.24 [‐0.37, ‐0.10]
33.3.4 at 2 weeks 4 857 Std. Mean Difference (IV, Random, 95% CI) ‐0.21 [‐0.34, ‐0.07]
33.3.5 at 4 weeks 6 1182 Std. Mean Difference (IV, Random, 95% CI) ‐0.27 [‐0.39, ‐0.16]
33.3.6 at 3 months 1 38 Std. Mean Difference (IV, Random, 95% CI) ‐0.12 [‐0.75, 0.52]
33.4 Suicidal ideation composite 3   Mean Difference (IV, Random, 95% CI) Subtotals only
33.4.1 at 24 hours 2 450 Mean Difference (IV, Random, 95% CI) ‐0.15 [‐0.44, 0.15]
33.4.2 at 72 hours 2 451 Mean Difference (IV, Random, 95% CI) ‐0.20 [‐0.49, 0.08]
33.4.3 at 1 week 3 660 Mean Difference (IV, Random, 95% CI) 0.01 [‐0.10, 0.13]
33.4.4 at 2 weeks 3 659 Mean Difference (IV, Random, 95% CI) ‐0.10 [‐0.22, 0.02]
33.4.5 at 4 weeks 3 647 Mean Difference (IV, Random, 95% CI) ‐0.04 [‐0.12, 0.05]