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. 2021 Sep 12;2021(9):CD011612. doi: 10.1002/14651858.CD011612.pub3

Comparison 34. Esketamine versus placebo (pre‐planned sensitivity analysis: excluding TRD populations).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
34.1 Response rate 2   Odds Ratio (M‐H, Random, 95% CI) Subtotals only
34.1.1 at 24 hours 2 451 Odds Ratio (M‐H, Random, 95% CI) 1.55 [1.03, 2.33]
34.1.2 at 72 hours 2 451 Odds Ratio (M‐H, Random, 95% CI) 1.34 [0.92, 1.96]
34.1.3 at 1 week 2 451 Odds Ratio (M‐H, Random, 95% CI) 1.23 [0.85, 1.78]
34.1.4 at 2 weeks 2 451 Odds Ratio (M‐H, Random, 95% CI) 1.57 [1.09, 2.28]
34.1.5 at 4 weeks 2 451 Odds Ratio (M‐H, Random, 95% CI) 1.70 [1.17, 2.46]
34.2 Remission rate 3   Odds Ratio (M‐H, Random, 95% CI) Subtotals only
34.2.1 at 24 hours 3 517 Odds Ratio (M‐H, Random, 95% CI) 2.35 [1.40, 3.92]
34.2.2 at 72 hours 3 517 Odds Ratio (M‐H, Random, 95% CI) 1.55 [0.91, 2.64]
34.2.3 at 1 week 3 517 Odds Ratio (M‐H, Random, 95% CI) 1.31 [0.86, 2.01]
34.2.4 at 2 weeks 3 517 Odds Ratio (M‐H, Random, 95% CI) 1.38 [0.93, 2.04]
34.2.5 at 4 weeks 3 517 Odds Ratio (M‐H, Random, 95% CI) 1.58 [1.10, 2.29]
34.3 Depression rating scale score 3   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
34.3.1 at 24 hours 3 514 Std. Mean Difference (IV, Random, 95% CI) ‐0.34 [‐0.52, ‐0.17]
34.3.2 at 72 hours 3 517 Std. Mean Difference (IV, Random, 95% CI) ‐0.30 [‐0.50, ‐0.11]
34.3.3 at 1 week 3 517 Std. Mean Difference (IV, Random, 95% CI) ‐0.21 [‐0.38, ‐0.04]
34.3.4 at 2 weeks 3 517 Std. Mean Difference (IV, Random, 95% CI) ‐0.14 [‐0.32, 0.03]
34.3.5 at 4 weeks 3 517 Std. Mean Difference (IV, Random, 95% CI) ‐0.27 [‐0.44, ‐0.10]
34.4 Suicidal ideation composite 2   Mean Difference (IV, Random, 95% CI) Subtotals only
34.4.1 at 24 hours 2 450 Mean Difference (IV, Random, 95% CI) ‐0.15 [‐0.44, 0.15]
34.4.2 at 72 hours 2 451 Mean Difference (IV, Random, 95% CI) ‐0.20 [‐0.49, 0.08]
34.4.3 at 1 week 2 451 Mean Difference (IV, Random, 95% CI) ‐0.15 [‐0.41, 0.11]
34.4.4 at 2 weeks 2 451 Mean Difference (IV, Random, 95% CI) ‐0.19 [‐0.43, 0.05]
34.4.5 at 4 weeks 2 451 Mean Difference (IV, Random, 95% CI) ‐0.15 [‐0.39, 0.09]