| Study name |
The Effect of S‐ketamine for Patients Undergoing Electroconvulsive Therapy (ECT) (ECT) |
| Methods |
RCT |
| Participants |
American Society of Anesthesiologists (ASA) Physical Status I‐II diagnose depressive disorders with DSM‐IV Without cognitive impairment Without ECT in past 6 months |
| Interventions |
Placebo Comparator: Propofol group
patients were treated with propofol 1 mg/kg and saline bolus infusion before ECT
Active Comparator: Ketamine group
patients were treated with propofol 1 mg/kg and ketamine 0.5 mg/kg bolus infusion before ECT
Experimental: S‐ketamine group
patients were treated with propofol 1 mg/kg and S‐ketamine 0.25 mg/kg bolus infusion before ECT |
| Outcomes |
Hamilton Depression Scale‐17 scores [ Time Frame: the 1 day after the last ECT ]the patients' depression were evaluated with Hamilton Depression Scale with 17 questions after ECT. The scores ranged 0‐68, and <7 were normal, the higher the score means more serious disease. Montgomery‐Asberg Depression Rating Scale scores [ Time Frame: the 1 day after the last ECT ]the patients' depression were evaluated with Montgomery‐Asberg Depression Rating Scale scores after ECT. The scores ranged 0‐60, and <17 were normal, the higher the score means more serious disease. |
| Starting date |
August 1, 2020 |
| Contact information |
qiuyan_mz@126.com |
| Notes |
NCT04399070 |
