Table 1.
Clinical and echocardiographic characteristics of the study cohorts
| ECHO Cohort | CMR Cohort | CT Cohort | |
|---|---|---|---|
| Number of Patients | 1052 | 160 | 752 |
| Age, y | 73 [64 – 79] | 70 [64 – 75] | 79 [72 – 85] |
| Gender, Male, n (%) | 603 (57.3) | 111 (69.4) | 441 (58.6) |
| Body Mass Index, kg/m2 | 26.9 [24.1 – 30.1] | 28.0 [25.6 – 31.2] | 27.4 [24.6 – 30.9] |
| Body Surface Area, m2 | 1.81 [1.65 – 1.94] | 1.86 [1.74 – 1.99] | 1.83 [1.69 – 1.97] |
| Heart Rate, bpm | 66 [60 – 75] | 64 [57 – 71] | 67 [60 – 76] |
| Systolic Blood Pressure, mmHg | 130 [117 – 145] | 148 [134 – 163] | 132 [120 – 147] |
| Diastolic Blood Pressure, mmHg | 72 [64 – 80] | 83 [77 – 92] | 71 [65 – 80] |
| Comorbidities | |||
| Hypertension, n (%) | 751 (71.4) | 108 (67.5) | 583 (77.6) |
| Diabetes Mellitus, n (%) | 286 (27.2) | 25 (15.6) | 221 (29.4) |
| Dyslipidemia, n (%) | 608 (57.8) | 71 (44.4) | 498 (66.3) |
| Obesity, n (%) | 277 (26.3) | 53 (33.1) | 230 (30.6) |
| Coronary Artery Disease, n (%) | 608 (57.8) | 60 (37.5) | 360 (47.9) |
| Echocardiography | |||
| LV Ejection Fraction, % | 63 [55 – 70] | 57 [52 – 62] | 63 [58 – 65] |
| Stroke Volume Index, mL | 38 [33 – 44] | 44 [37 – 49] | 41 [35 – 48] |
| AV Peak Velocity, m/s | 3.2 [2.6 – 3.9] | 3.9 [3.3 – 4.4] | 4.1 [3.3 – 4.6] |
| AV Mean Gradient, mmHg | 23 [15 – 35] | 34 [22 – 43] | 41 [26 – 52] |
| Aortic Valve Area, cm2 | 0.99 [0.76 – 1.23] | 0.87 [0.73 – 1.10] | 0.79 [0.62 – 1.01] |
| Aortic Valve Area Index, cm2/m2 | 0.55 [0.42 – 0.68] | 0.46 [0.39 – 0.58] | 0.43 [0.35 – 0.55] |
| AS Severity Grading, n (%) | |||
| Mild/Moderate AS | 349 (33.2) | 66 (41.2) | 183 (24.3) |
| Discordant Grading | 514 (48.9) | 48 (30.0) | 186 (24.7) |
| Severe AS | 189 (18.0) | 46 (28.7) | 383 (50.9) |
Values are median (interquartile range) or n (%). AS = aortic stenosis; AV -= aortic valve; CMR = cardiovascular magnetic resonance; CT = computed tomography; ECHO = echocardiography; LV = left ventricular.