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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Semin Cell Dev Biol. 2021 Jul 17;118:150–162. doi: 10.1016/j.semcdb.2021.07.007

Table 1.

MicroRNAs in cardiac regeneration in large animal (pig) models

Name Target cells Functional role and mechanism Intervention approach Clinical trial Ref
miR-15b CMs pro-apoptosis; via targeting Arl2 and Bcl2 LNA antimiR - [72]
miR-21-5p M1 macrophages and endothelial cells anti-inflammation and pro-angiogenesis; via targeting SPRY1/VEGFA and PDGF-BB signaling agomiR + nanoparticles - [79]
miR-92a endothelial cells anti-angiogenesis; via targeting pro-angiogenic protein Itga5 antagomir Yes [54,75]
miR-146b-5p CFs, endothelial cells and macrophages pro-fibrotic, anti-angiogenesis and inhibit reparative macrophages; via targeting interleukin 1 receptor associated kinase 1 (IRAK1) and carcinoembryonic antigen related cell adhesion molecule 1 (CEACAM1) antagomir - [81]
miR-199a-3p CMs pro-proliferative; via targeting Hippo/YAP1 pathway via TAOK1, β-TrCP and Cofilin2 AAV6 - [63]