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. Author manuscript; available in PMC: 2022 Sep 15.
Published in final edited form as: Neuropharmacology. 2021 Jul 8;196:108702. doi: 10.1016/j.neuropharm.2021.108702

Figure 4. LH α1 adrenergic receptor activation blunts binge-like ethanol intake in C57BL6/J mice.

Figure 4.

α1 agonism via LH-targeted phenylephrine (PHEN) blunted total ethanol intake (A; n=17) but not overall BECs (B; n=17) in the DID paradigm while failing to alter intake of a 3% sucrose solution (C; n=15). Male and female data are collapsed as we failed to observe an interaction of sex and drug during LH α1 manipulation. Approximate cannula placements (D). (E) Further analyses of ethanol intake data indicated that PHEN blunted intake in mice with High baseline ethanol intake (upper 50% of a median-split) and not in mice with Low baseline intake (lower 50% of a median-split). All values represent mean ± SEM. * represents p<0.05 in paired t-test.