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. Author manuscript; available in PMC: 2022 Sep 15.
Published in final edited form as: Neuropharmacology. 2021 Jul 8;196:108702. doi: 10.1016/j.neuropharm.2021.108702

Figure 6. LH α2 adrenergic receptor blockade fails to blunt binge-like ethanol intake in C57BL6/J mice.

Figure 6.

α2 antagonism via APZ failed to significantly alter total ethanol intake (A; n=21), BECs (B; n=21), or intake of a 3% sucrose solution (C; n=20). Approximate cannula placements within the LH (D). (E) Further analyses of ethanol intake data indicated that the high dose of APZ blunted intake in mice with High baseline ethanol intake (upper 50% of a median-split) and that the low dose of APZ increased ethanol intake in mice with Low baseline intake (lower 50% of a median-split). All values represent mean ± SEM.