Table 1.
Evidence showing alterations in microRNA expression in postmortem prefrontal cortex samples of psychiatric patients. The methods for measuring microRNA expression vary across studies, most likely explaining the variability of findings.
| microRNAs | Cortex region | Human condition | Reference |
|---|---|---|---|
| miR-26b, miR-30b, miR-29b, miR-195, miR-92, miR-30a-5p, miR-30d, miR-20b, miR-29c, miR-29a, miR-212, miR-106b, miR-7, miR-24, miR-30e, miR-9-3p | PFC BA-9 | Schizophrenia vs. non-psychiatric control subjects | Perkins et al., 2007 [149] |
| miR-346 | BA46 | Zhu et al., 2009 [150] | |
| miR-34a, miR-132, miR-212, miR-544, miR-7, miR-154, | Dorsolateral PFC BA-46 | Schizophrenia vs. control individuals | Kim et al., 2010 [151] |
| miR-504, miR-454, miR-29a, miR-520c-3p, miR-140-3p, miR-145, miR-767-5p, miR-22, miR-145, miR-874, miR-133b, miR-154, miR-32, miR-573, miR-889 | Bipolar vs. control individuals | ||
| let-7d, miR-128a, miR-16, miR-181a, b, miR-20a, miR-219, miR-27a, miR-29c, miR-7 | Dorsolateral PFC BA-9 | Schizophrenia vs. control individuals | Beveridge et al., 2010 [152] |
| miR-553, miR-369-3p, miR-18a, miR-339-5p, miR-1, miR-7, miR-196a, miR-301a, miR-144, let-7g, miR-153, let-7f, miR-203, miR-34c-5p, miR-101, miR-376c, miR-665, miR-152, miR-194, miR-423-5p, miR-515-3p, miR-374b, miR-140, miR-519b-3p, miR-586, miR_135b, miR-92a, miR-15b, miR-580, miR-146a, miR-454-3p, miR-380, miR-652, miR-802, miR-196b | PFC | Alcohol user vs. control | Lewohl et al., 2011 [153] |
| miR-328, miR-17-5p, miR-134, miR-652, miR-382, and miR-107 | Dorsolateral PFC BA-46 | Schizophrenia/schizoaffective disorder vs. control individuals | Santarelli et al., 2011 [154] |
| miR-330, miR-33, miR-193b, miR-545, miR-138, miR-151, miR-210, miR-324-3p, miR-22, miR-425, miR-181a, miR-106b, miR-193a, miR-192, miR-301, miR-27b, miR-148b, miR-338, miR-639, miR-15a, miR-186, miR-99a, miR-190, miR-339 | BA-9 | Schizophrenia vs. control individuals AND Bipolar vs. control individuals | Moreau et al., 2011 [155] |
| miR-132 | Dorsolateral BA-46 | Schizophrenia vs. control individuals | Miller et al., 2012 [156] |
| miR-383, miR-32, miR-490-5p, miR-165b, miR-513-5p, miR-876-3p, miR-449b, miR-297, miR-188-5p, miR-187 |
miR-142-5p, miR-137, miR-489, miR-148b, miR-101, miR-324-5p, miR-301a, miR-146a, miR-335, miR-494, miR-20b, miR-376a, miR-190, miR-155, miR-660, miR-130a, miR-27a, miR-497, miR-10a, miR-20a, miR-142-3p |
Bipolar vs. control individuals PFC BA-9 |
Depressed suicide vs. control individuals |
| Smalheiser et al., 2012 [157] | |||
| miR-185 | Anterior PFC BA-10 | Depression vs. control individuals | Maussion et al., 2012 [158] |
| hsa-miR-375, hsa-miR-3065-5p, hsa-miR-488-star, hsa-miR-299-3p, hsa-miR-377, hsa-mir-516a-2, hsa-miR-767-5p, hsa-miR-493, hsa-miR-379, hsa-miR-105, hsa-miR-29b, hsa-miR-149 | Frontal BA-9 | Alcohol user vs. control | Manzardo et al., 2013 [159] |
| miR-31, miR-33, miR-96, miR-28, miR-30e-5p, miR-199a, miR-501, miR-504, miR-15b, miR-29c, miR-455, miR-380-3p, miR-323, miR-527, miR-93, miR-32, miR-20b, miR-516-5p, miR-92, miR-30a-3p, miR-497 etc. | PFC BA-9 | Differential expression for schizophrenia, bipolar and control groups | Banigan et al., 2013 [160] |
| miR-17-5p, miR-331-5p, miR-16-5p, miR-187-3p, miR-106b-5p, miR-485-5p, miR-129-2-3p, miR-454-3p, miR-185-5p, miR-429-3p, miR-511, miR-18a-5p, miR-590-5p, miR-106a-5p, miR-145-5p, miR-642a-5p, miR-625-5p, miR-508-3p, miR-219-2-3p | PFC BA-10 | Schizophrenia vs. control individuals | Smalheiser et al., 2014 [161] |
| miR-17-5p, miR-145-5p, miR-579, miR-106b-5p, miR-485-5p, miR-370, miR-500a-5p, miR-34a-5p, miR-29c-3p | Bipolar vs. control individuals | ||
| miR-508-3p, miR-152-3p | Depression vs. control individuals | ||
| miR-34c-5p, miR-139-5p, miR-195, miR-320c | Ventrolateral PFC BA-44 | Depression vs. control individuals | Lopez et al., 2014 [162] |
| miR-1202 | Ventrolateral PFC BA-44 | Depression vs. control individuals | Lopez et al., 2014 [163] |
| miR-218 | Ventrolateral PFC BA-44 | Depression vs. control individuals | Torres-Berrio et al., 2017 [79] |
| miR-124 | Dorsolateral PFC BA-46 | Depression vs. control individuals | Roy et al., 2017 [164] |
| miR-146a-5p, miR-146b-5p, miR-24-3p, miR-425-3p | Ventrolateral PFC BA-44 | Depression vs. control individuals | Lopez et al., 2017 [165] |
| miR-19a-13p | Dorsolateral BA-10 | Depression vs. control individuals | Wang et al., 2018 [166] |
| miR-3162, miR-936 | BA-46 | Schizophrenia vs. control individuals | Hu et al., 2019 [167] |
| miR-30e | Dorsolateral PFC BA-9 | Depression vs. control individuals | Gorinski et al., 2019 [168] |