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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Hum Mutat. 2021 Aug 1;42(10):1321–1335. doi: 10.1002/humu.24260

FIGURE 4:

FIGURE 4:

Expression patterns of claudin 9 in mouse inner ear. Cldn9 (Probe-Mm-Cldn9, Red) is expressed in the outer and inner hair cells, supporting cells, stria vascularis and Reissner’s membrane at embryonic (E) days E14.5, E18.5, and postnatal (P) days P3 and P30. The intensity of the signal detecting Cldn9 increases from E14.5 to P3 and then decreases from P3 to P30. Expression of Cldn6 (Probe-Mm-Cldn6–01-C3, blue) in supporting cells, stria vascularis and Reissner’s membrane is present at E14.5, E18.5 and P3, while in the outer and inner hair cells, Cldn6 is expressed only embryonically based on analyses at ages E14.5 and E18.5. No Cldn6 signal is detected in the entire organ of Corti at P30. Hair cells were labeled using Myo7a (Probe-Mm-Myo7a-C2, green) at the ages E18.5, P3 and P30. Scale bars are 50 μm in panels and 10 μm in insets. SV; stria vascularis, RM; Reissner’s membrane, OC; organ of Corti, OHC; Outer Hair Cells, IHC; Inner Hair Cells.