Female (58 years of age) with typical chest pain, family history of coronary artery disease and abnormal exercise tolerance test. Coronary computed tomography angiography (CCTA) showed obstructive disease in the left anterior descending (LAD) artery (arrows), confirmed at invasive coronary angiography and treated with a stent. Two years later she experienced a non-ST elevation myocardial infarction. (A) A curved planar reformation with diffuse noncalcified plaque (red) and calcified plaque (yellow). Three-dimensional reformats of the proximal (B) and mid-distal LAD (C) show non calcified (red), low-attenuation (orange), and calcified (yellow) plaque, and coronary lumen (blue).