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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Neurobiol Learn Mem. 2021 Jul 21;184:107490. doi: 10.1016/j.nlm.2021.107490

Fig. 2.

Fig. 2.

Schematic diagram showing a circuit by which the BLA influences dorsal hippocampus functioning. Work highlighted in this review indicates that optogenetically stimulating the BLA inputs to the medial entorhinal cortex with bursts of 8 Hz pulses alters the consolidation of spatial memories known to depend on the dorsal hippocampus. Such stimulation given with bursts of 8 Hz pulses also alters dorsal hippocampal levels of the plasticity-associated protein ARC in males while decreasing ARC levels in the dorsal striatum of females. Finally, as depicted in this figure, electrophysiological recordings reveal that 8 Hz bursts of stimulation to BLA axons in the medial entorhinal cortex increase local-field potential (LFP) power in the theta (6–10 Hz) range both in the medial entorhinal and downstream in the dorsal hippocampus (adapted from Wahlstrom et al., 2018, and from presentation slides kindly provided by Dr. Krista Wahlstrom with illustration assistance from Dr. Sean Farley). Together, these findings point to this circuit as a strong candidate for how the BLA influences dorsal hippocampal memory-related activity. See main article text for abbreviation definitions.