TABLE 3.
Neonatal outcomes
| Neonatal Outcome | No anemia (n=156,349) | Anemia (n=10,217) | P value |
|---|---|---|---|
| Composite neonatal outcomea (n=166,566) | 20,716 (13.3)b | 1579 (15.5)b | <.001b |
| 5-min Apgar score <7 (n=166,566) | 2816 (1.8)b | 227 (2.2)b | .002b |
| HIE (n=165,666) | 25 (0.02) | 2 (0.02) | .777 |
| RDS (n=166,566) | 5153 (3.3)b | 296 (2.9)b | .028b |
| NEC (n=164,382) | 218 (0.2) | 24 (0.2) | .216 |
| Seizures (n=164,382) | 305 (0.2) | 24 (0.2) | .395 |
| ICH (n=166,566) | 463 (0.3) | 26 (0.3) | .451 |
| Neonatal sepsis (n=166,566) | 4146 (2.7) | 287 (2.8) | .339 |
| PVH or IVH (n=166,566) | 877 (0.6) | 60 (0.6) | .730 |
| Neonatal death (n=150,739) | 466 (0.3) | 22 (0.2) | .065 |
| NICU admission (n=166,566) | 19,676 (12.6)b | 1525 (14.9)b | <.001b |
| Antenatal fetal distress (n=166,566) | 8088 (5.2)b | 819 (8.0)b | <.001b |
| Intrapartum fetal distress (n=166,565) | 9861 (6.3)b | 769 (7.4)b | <.001b |
| Birthweight (g) (n=165,412) | 3236.5±601.1 | 3237.8±613.9 | .825 |
| Birthweight <2500 g (n=166,566) | 14,045 (9.0)b | 1001 (9.8)b | .005b |
| Neonatal anemia or transfusion (n=166,566) | 3231 (2.1) | 225 (2.2) | .351 |
| Neonatal anemia (n=166,566) | 3116 (2.0) | 223 (2.2) | .185 |
| Neonatal transfusion (n=166,566) | 236 (0.2)b | 6 (0.1)b | .018b |
Data are presented as number (percentage) or mean±standard deviation.
HIE, hypoxic ischemic encephalopathy; ICH, intracranial hemorrhage; IVH, intraventricular hemorrhage; NEC, necrotizing enterocolitis; NICU, neonatal intensive care unit; PVH, periventricular hemorrhage; RDS, respiratory distress syndrome.
a
Composite includes 5-minute Apgar score of <7, HIE, RDS, NEC, seizures, ICH, neonatal sepsis, PVH/IVH, neonatal death, NICU admission;
b
Denotes statistical significance.