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. Author manuscript; available in PMC: 2022 Sep 25.
Published in final edited form as: Neurosci Lett. 2021 Jul 16;762:136117. doi: 10.1016/j.neulet.2021.136117

Figure 3. Retrieval of the lysosomal sorting receptors requires CLN3.

Figure 3.

CLN3 coordinates the efficient interactions between Rab7, retromer and the lysosomal sorting receptor, sortilin at late endosomes. In cells lacking functional CLN3, these interactions are deficient, resulting in the lysosomal degradation of the receptors