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. 2021 Sep 11;11(5):1805–1828. doi: 10.1007/s13555-021-00586-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 1 — Patient with HIES and severe AD. Panel i and ii: Before dupilumab, on MTX 25 mg weekly. Panel iii and iv: 1 month after dupilumab initiation plus MTX 25 mg weekly. Photos courtesy of Dr. M Gooderham. HIES hyper-IgE syndrome, AD atopic dermatitis, MTX methotrexate