Fig. 5. Identification of key genes in HF-related stroke. (a) Identification of hub genes in stroke-related key modules. The high correlation between GS and MM implies that hub genes in the Magenta and Darkolivegreen modules are highly correlated with cardioembolic stroke. The genes with the top five MM values were selected as hub genes in each stroke-related key module. (b) Identification of common genes of HF-related stroke. The common genes between two HF-related modules and two stroke-related modules are shown in the four circos plots, where the inner circle represents gene lists while the color of the outer circle determines which module the genes in the inner circle belong to, and purple curves link identical genes between two modules. A PPI network constituted by common genes is presented at the center of the diagram. GS: gene significance; MM: module membership; HF: heart failure; PPI: protein‒protein interaction; cor: correlation.