Figure 2.

Best change from baseline in PSA in patients with an ATM alteration (A), CDK12 alteration (B), CHEK2 alteration (C), or other DDR gene alteration (D). PSA increases for patients 1–5 were 319%, 142%, 126%, 109%, and 106%; bars were capped at 100% for visual clarity. Patients 55, 56, 57, 61, 62, 63, and 64 had 2 distinct CDK12 alterations identified through tissue and/or plasma testing and were considered to have biallelic loss. Abbreviations: CR, complete response; PR, partial response; PSA, prostate-specific antigen; SLD, sum of the longest diameter.