TABLE 3.
Direct gene targets of miR‐32 in cancers
| Disease | miR‐32 change | Target | Cell lines | In vivo verification | Target function | References |
|---|---|---|---|---|---|---|
| OS | Down | HMGB1 | Five OS cell linesa | No | Induced apoptosis and impeded proliferation, migration, and invasion | Lou et al. (2020) Ref:52 |
| Breast cancer | Down | TOB1 | Human TNBC cell lines | No | Inhibits proliferation and induce apoptosis | Wang et al. (2020c) Ref:14 |
| Retinoblastoma | Down | NOTCH | Retinoblastoma cell lines (Weri‐Rb1 and Y79) | Yes | Inhibit EMT | Gao et al. (2020)Ref:57 |
| Ovarian cancer | Down | BTLA | Human SKOV3 and IOSE80 cells | No | Inhibits the proliferation, migration, and invasion | Zhang et al. (2020) Ref:60 |
| AML | Down | DNAJB9 | HL60 and HL60/ADR cells | No | Induce autophagy | Wang et al. (2020a)Ref:62 |
| Myeloma | Up | PTEN | U266 cells | No | Enhance the proliferation and inhibits apoptotic | Sun et al. (2020b)Ref:67 |
| CRC | Down | SKIL | LoVo, RKO, SW480, and HT‐29 | Yes | Inhibits cell proliferation, metastasis, and EMT process | Ye et al. (2019)Ref:76 |
| Glioma | Down | EZH2 | U87, U251, A172, U118 and primary normal human astrocytes | No | Inhibits cell proliferation and metastasis | Chinaranagari et al. (2014)Ref:87 |
| Nasopharyngeal carcinoma | Up | LATS2 | C666‐1 (CC‐Y1082) and CNE2 (CC‐Y1119) | No | Inhibits apoptosis | Wang et al. (2019b)Ref:90 |
| ESCC | Up | CXXC5 | EC9706 and KYSE450 | Yes | Promote migration, invasion, adhesion | Liu et al. (2019a)Ref:17 |
| Colorectal cancer | Up | TOB1 | SW480 | No | Promote migration and invasion | Liang et al. (2019)Ref:69 |
| Colorectal cancer | Up | BMP5 | Lovo, HCT116, HT‐29 | No | Promoted cell proliferation and migration | Chen et al. (2018)Ref:72 |
| Cervical cancer | Down | HOXB8 | siHa | No | Suppressed cell proliferation, invasion and migration | Liu et al. (2019b)Ref:94 |
| PC | Up | KLF4 | PC‐3, DU145, PANC‐1 and BxPC‐3 | No | Inhibit cell apoptosis, promoted cell proliferation | Ref:100,103Gao et al. (2017) and Zhang et al. (2018) |
| Lung cancer | Down | TWIST1 | H1299 and A549 | Yes | Inhibits cell proliferation and EMT | Li and Wu (2016)Ref:85 |
| Melanoma | Down | MCL‐1 | ARF−/−,INK4a−/− melanocytes and Primary melanocyte | Yes | Enhance apoptosis | Mishra et al. (2016)REF:10 |
| Gastric cance | Up | KLF4 | GES‐1, MGC8‐03, HGC‐27, NCI‐N87, AGS, SGC‐7901, MKN28, MKN‐45 and KATO‐III | No | Promotes cell proliferation, migration and invasion | Yan et al. (2015)REF:107 |
Abbreviations: AML, acute myeloid leukemia; CRC, colorectal cancer; ESCC, esophageal squamous cell carcinoma; OS, osteosarcoma; PBMCs, peripheral blood mononuclear cells; PC, prostate cancer.
a
Five OS cell lines: U2OS, Saos‐2, 143B, HOS, and MG63 and the hFOB1.19 cells.