FIGURE 4.

Lean MSCs decrease both M1 and M2 macrophage intensities while obese MSCs have the opposite effect when in co‐culture with M1 macrophages. Macrophages co‐cultured with MSCs isolated from lean subjects decreased both M1 (double‐positivity to CD68 in red and iNOS in green) and M2 (double‐positive to CD68 in red and mannose receptor‐1 in green intensity, while these remained high in macrophages co‐cultured with MSCs isolated from obese subjects. M1/M2 intensity ratios remained unaltered. *p < 0.05 vs. M0, ^# p < 0.05 vs. M1+obese MSCs