Table 2.
Thrombotic and hemorrhagic events
| Variable | ET (n = 139) | pre-PMF (n = 42) | PV (n = 124) | PMF (n = 30) | Total (n = 335) |
|---|---|---|---|---|---|
| Initial thrombotic event | |||||
| Cerebrovascular | |||||
| Stroke | 18 (12.9) | 8 (19.0) | 29 (23.4) | 0 | 55 (16.4) |
| TIA | 4 (2.9) | 2 (4.8) | 1 (0.8) | 0 | 7 (2.1) |
| VST | 1 (0.7) | 0 | 0 | 0 | 1 (0.3) |
| Any | 23 (16.5) | 10 (23.8) | 30 (24.2) | 0 | 63 (18.8) |
| Coronary | |||||
| ACS | 10 (7.2) | 1 (2.4) | 7 (5.6) | 2 (6.7) | 20 (6.0) |
| Other | 5 (3.6) | 3 (7.1) | 4 (3.2) | 2 (6.7) | 14 (4.2) |
| Any | 15 (10.8) | 4 (9.5) | 11 (8.8) | 4 (13.4) | 34 (10.1) |
| Splanchnic | |||||
| Arterial | 1 (0.7) | 0 | 0 | 0 | 1 (0.3) |
| Venous | 0 | 1 (2.4) | 3 (2.4) | 0 | 4 (1.2) |
| Any | 1 (0.7) | 1 (2.4) | 3 (2.4) | 0 | 5 (1.5) |
| Peripheral | |||||
| Arterial | 1 (0.7) | 0 | 2 (1.6) | 0 | 3 (0.9) |
| Venous | 0 | 1 (2.4) | 1 (0.8) | 0 | 2 (0.6) |
| Any | 1 (0.7) | 1 (2.4) | 3 (2.4) | 0 | 5 (1.5) |
| Atherosclerosis obliterans | 3 (2.2) | 0 | 1 (0.8) | 0 | 4 (1.2) |
| Total | 43 (30.9) | 16 (38.1) | 49 (39.5) | 4 (13.3) | 112 (33.4) |
| Vessels involved in initial thrombotic events | |||||
| Arterial | 42 (30.2) | 14 (33.3) | 45 (36.3) | 4 (13.3) | 105 (31.3) |
| Venous | 1 (0.7) | 2 (4.8) | 4 (3.2) | 0 | 7 (2.1) |
| Any | 43 (30.9) | 16 (38.1) | 49 (39.5) | 4 (13.3) | 112 (33.4) |
| Pooled thrombotic events | |||||
| Cerebrovascular | |||||
| Stroke | 21 | 8 | 35 | 0 | 64 |
| TIA | 4 | 2 | 1 | 0 | 7 |
| VST | 1 | 0 | 0 | 0 | 1 |
| Coronary | |||||
| ACS | 11 | 1 | 9 | 2 | 23 |
| Others | 7 | 3 | 5 | 2 | 17 |
| Splanchnic | |||||
| Arterial | 1 | 0 | 0 | 0 | 1 |
| Venous | 0 | 1 | 3 | 0 | 4 |
| Peripheral | |||||
| Arterial | 0 | 0 | 3 | 0 | 3 |
| Venous | 0 | 1 | 1 | 0 | 2 |
| Atherosclerosis obliterans | 3 | 0 | 1 | 0 | 4 |
| Total | 48 | 16 | 58 | 4 | 126 |
| Initial hemorrhagic event | |||||
| CNS | 1 (0.7) | 0 | 1 (0.8) | 0 | 2 (0.6) |
| Gastrointestinal | 6 (4.3) | 4 (9.5) | 10 (9.1) | 0 | 20 (6.0) |
| Genitourinary | 1 (0.7) | 0 | 0 | 0 | 1 (0.3) |
| Soft tissue | 1 (0.7) | 0 | 2 (1.6) | 1 (3.3) | 4 (1.2) |
| Total | 9 (6.5) | 4 (9.5) | 13 (10.5) | 1 (3.3) | 27 (8.1) |
| Pooled hemorrhagic events | |||||
| CNS | 1 | 0 | 2 | 0 | 3 |
| Gastrointestinal | 6 | 4 | 11 | 0 | 21 |
| Genitourinary | 1 | 0 | 0 | 0 | 1 |
| Soft tissue | 1 | 0 | 2 | 1 | 4 |
| Total | 9 | 4 | 15 | 1 | 29 |
Values are presented as number (%).
ET, essential thrombocythemia; pre-PMF, prefibrotic/early primary myelofibrosis; PV, polycythemia vera; PMF, primary myelofibrosis; TIA, transient ischemic attack; VST, venous sinus thrombosis; ACS, acute coronary syndrome; CNS, central nervous system.