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. 2021 Mar 6;21(5):483–486. doi: 10.1007/s40256-021-00471-z
We disagree with the latest European Society of Cardiology guidelines about the preferred choice concerning P2Y12 inhibitors. Although the ISAR-REACT 5 data support the “one size does not fit all” concept, we believe that the guidelines do not provide sufficient evidence to support a preferred drug or strategy.
Giving a level-IIa recommendation for prasugrel over ticagrelor in patients with NSTE-ACS undergoing PCI seems overrated. In our opinion, equipoise remains, and more data are needed to settle the doubt between these two strategies.