. 2021 Jun 16;46(10):4647–4659. doi: 10.1007/s00261-021-03010-1

Table 3.

Comparison of accuracy improvement in diagnosis of target lesions as benign or malignant (post-contrast versus pre-contrast)

Reader	Treatment	Total	Accuracy^a			Accuracy Improvement (%)	p-value^c
Reader	Treatment	Total	Improved	Same	Worsened	Accuracy Improvement (%)	p-value^c
1	SonoVue	157	38	100	19	24.2
	Sonazoid	160	29	114	17	18.1
	Difference (95% CI^b)				6.1 ( − 5.0, 17.2)		0.0013
2	SonoVue	158	23	119	16	14.6
	Sonazoid	163	36	107	20	22.1
	Difference (95% CI^b)				− 7.5 (− 18.4, 3.5)		< .0001
3	SonoVue	162	27	115	20	16.7
	Sonazoid	165	28	121	16	17.0
	Difference (95% CI^b)				− 0.3 (− 11.3, 10.7)		< .0001

^aPost-contrast versus pre-contrast diagnosis when compared with the reference diagnosis

^bExact binomial 95% confidence interval

^cp-values based on the Farrington-Manning score test for noninferiority