Fig. 7.
Role of Endothelin 1 after eNOS inhibition in pulmonary and systemic vasomotor control in DM + HC + CKD and Healthy swine. Transpulmonary gradient (TPG) as a function of cardiac index decreased significantly after endothelin receptor A and B inhibition (ETA + Bi) in the presence of NOS inhibition (NOSi) in Healthy (A) but not in DM + HC + CKD (D). Pulmonary vascular resistance (PVR) decreased significantly in response to ETA + Bi after NOSi in Healthy (B), while in DM + HC + CKD (E) ETA + Bi additional to NOSi did not result in pulmonary vasodilation. In the systemic vasculature, effect of ETA + Bi during NOSi was only observed at rest in Healthy (C), but resulted in vasodilatation at rest and during exercise in DM + HC + CKD (F). Healthy n = 6, DM + HC + CKD n = 4. Values are mean ± SEM. *P ≤ 0.05 for effect ETA + Bi within group, †P ≤ 0.05, (†)P ≤ 0.10 for interaction ETA+Bi × group